Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Science. 2015 Mar 27;347(6229):1477-80. doi: 10.1126/science.1261821. Epub 2015 Mar 12.
Wireless deep brain stimulation of well-defined neuronal populations could facilitate the study of intact brain circuits and the treatment of neurological disorders. Here, we demonstrate minimally invasive and remote neural excitation through the activation of the heat-sensitive capsaicin receptor TRPV1 by magnetic nanoparticles. When exposed to alternating magnetic fields, the nanoparticles dissipate heat generated by hysteresis, triggering widespread and reversible firing of TRPV1(+) neurons. Wireless magnetothermal stimulation in the ventral tegmental area of mice evoked excitation in subpopulations of neurons in the targeted brain region and in structures receiving excitatory projections. The nanoparticles persisted in the brain for over a month, allowing for chronic stimulation without the need for implants and connectors.
无线深部脑刺激明确的神经元群体可以促进完整的脑回路的研究和治疗神经紊乱。在这里，我们通过磁纳米粒子激活热敏性辣椒素受体 TRPV1 来证明微创和远程神经兴奋。当暴露于交变磁场时，纳米粒子耗散由滞后产生的热量，引发 TRPV1(+)神经元的广泛和可逆的发射。在小鼠腹侧被盖区的无线磁热刺激引起靶向脑区和接受兴奋性投射的结构中的神经元亚群兴奋。纳米粒子在大脑中持续存在一个多月，允许在没有植入物和连接器的情况下进行慢性刺激。
