Xiyuan Li, Dechao Bu, Liang Sun, Yang Wu, Shuangsang Fang, Hui Li, Haitao Luo, Chunlong Luo, Wenzheng Fang, Runsheng Chen, Yi Zhao
Institute of Computing Technology Chinese Academy of Sciences, Bioinformatics Research Group, Advanced Computing Research Laboratory, Beijing, China.
Beijing Zhongke Jingyun Technology Company Ltd, Medicine. Beijing, China.
Curr Protoc Bioinformatics. 2017 Jun 27;58:12.16.1-12.16.19. doi: 10.1002/cpbi.25.
NONCODE is a comprehensive database that aims to present the most complete collection and annotation of non-coding RNAs, especially long non-coding RNAs (lncRNA genes), and thus NONCODE is essential to modern biological and medical research. Scientists are producing a flood of new data from which new lncRNA genes and lncRNA-disease relationships are continually being identified. NONCODE assimilates such information from a wide variety of sources including published articles, RNA-seq data, micro-array data and databases on genetic variation (dbSNP) and genome-wide associations (GWAS). NONCODE organizes all this information and makes it freely available to the public via the Internet. The NONCODE protocol provides step-by-step instructions on how to browse and search lncRNA information such as sequence, expression, and disease relationships, how to use the tools for functional prediction, species conservation assays, blast analysis, identifier conversion, and, finally, how to submit sequences to identify lncRNA genes. As of Dec 2016, NONCODE has cataloged 487,851 lncRNA genes sequenced from 16 species. © 2017 by John Wiley & Sons, Inc.
NONCODE是一个综合数据库，旨在呈现非编码RNA（尤其是长链非编码RNA基因，即lncRNA基因）最完整的集合与注释，因此NONCODE对现代生物学和医学研究至关重要。科学家们正在产生大量新数据，从中不断发现新的lncRNA基因以及lncRNA与疾病的关系。NONCODE整合来自各种来源的此类信息，包括已发表文章、RNA测序数据、微阵列数据以及关于基因变异（dbSNP）和全基因组关联（GWAS）的数据库。NONCODE整理所有这些信息，并通过互联网向公众免费提供。NONCODE协议提供了逐步指导，说明如何浏览和搜索lncRNA信息，如序列、表达和疾病关系，如何使用功能预测、物种保守性分析、比对分析、标识符转换工具，最后说明如何提交序列以鉴定lncRNA基因。截至2016年12月，NONCODE已编目了来自16个物种的487,851个lncRNA基因。© 2017约翰威立父子出版公司
