小鼠胚胎干细胞命运调控中的多能性与表观遗传因子
Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate Regulation.
作者信息
Morey Lluis, Santanach Alexandra, Di Croce Luciano
机构信息
Center for Genomic Regulation, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain.
Center for Genomic Regulation, Barcelona, Spain Universitat Pompeu Fabra, Barcelona, Spain Institució Catalana de Recerca i Estudis Avançats, Barcelona, Spain
出版信息
Mol Cell Biol. 2015 Aug;35(16):2716-28. doi: 10.1128/MCB.00266-15. Epub 2015 Jun 1.
Abstract
Embryonic stem cells (ESCs) are characterized by their ability to self-renew and to differentiate into all cell types of a given organism. Understanding the molecular mechanisms that govern the ESC state is of great interest not only for basic research-for instance, ESCs represent a perfect system to study cellular differentiation in vitro-but also for their potential implications in human health, as these mechanisms are likewise involved in cancer progression and could be exploited in regenerative medicine. In this minireview, we focus on the latest insights into the molecular mechanisms mediated by the pluripotency factors as well as their roles during differentiation. We also discuss recent advances in understanding the function of the epigenetic regulators, Polycomb and MLL complexes, in ESC biology.
摘要
胚胎干细胞（ESCs）的特点是具有自我更新能力，并能分化为特定生物体的所有细胞类型。了解调控胚胎干细胞状态的分子机制不仅对基础研究具有重要意义——例如，胚胎干细胞是体外研究细胞分化的理想系统——而且对其在人类健康方面的潜在影响也很重要，因为这些机制同样参与癌症进展，并且可用于再生医学。在这篇小型综述中，我们重点关注多能性因子介导的分子机制的最新见解及其在分化过程中的作用。我们还讨论了在理解表观遗传调节因子、多梳蛋白和混合谱系白血病（MLL）复合物在胚胎干细胞生物学中的功能方面的最新进展。
相似文献
1
Pluripotency and Epigenetic Factors in Mouse Embryonic Stem Cell Fate Regulation.小鼠胚胎干细胞命运调控中的多能性与表观遗传因子
Mol Cell Biol. 2015 Aug;35(16):2716-28. doi: 10.1128/MCB.00266-15. Epub 2015 Jun 1.
2
Gene dynamics of core transcription factors for pluripotency in embryonic stem cells.胚胎干细胞中多能性核心转录因子的基因动力学
J Biosci Bioeng. 2015 Apr;119(4):406-9. doi: 10.1016/j.jbiosc.2014.09.011. Epub 2014 Nov 3.
3
Cell cycle and pluripotency: Convergence on octamer‑binding transcription factor 4 (Review).细胞周期与多能性：Octamer-binding transcription factor 4（OCT4）的趋同作用（综述）。
Mol Med Rep. 2017 Nov;16(5):6459-6466. doi: 10.3892/mmr.2017.7489. Epub 2017 Sep 13.
4
Transient pairing of homologous Oct4 alleles accompanies the onset of embryonic stem cell differentiation.同源Oct4等位基因的瞬时配对伴随着胚胎干细胞分化的开始。
Cell Stem Cell. 2015 Mar 5;16(3):275-88. doi: 10.1016/j.stem.2015.02.001.
5
The RNA-binding protein Unr prevents mouse embryonic stem cells differentiation toward the primitive endoderm lineage.RNA 结合蛋白 Unr 可防止小鼠胚胎干细胞向原始内胚层谱系分化。
Stem Cells. 2011 Oct;29(10):1504-16. doi: 10.1002/stem.712.
6
Gene expression signatures defining fundamental biological processes in pluripotent, early, and late differentiated embryonic stem cells.定义多能性、早期和晚期分化胚胎干细胞中基本生物学过程的基因表达特征。
Stem Cells Dev. 2012 Sep 1;21(13):2471-84. doi: 10.1089/scd.2011.0637. Epub 2012 Apr 17.
7
Regulation of stem cell pluripotency and differentiation involves a mutual regulatory circuit of the NANOG, OCT4, and SOX2 pluripotency transcription factors with polycomb repressive complexes and stem cell microRNAs.干细胞多能性和分化的调控涉及NANOG、OCT4和SOX2多能性转录因子与多梳抑制复合物及干细胞微小RNA之间的相互调控回路。
Stem Cells Dev. 2009 Sep;18(7):1093-108. doi: 10.1089/scd.2009.0113.
8
Role of SOX2 in maintaining pluripotency of human embryonic stem cells.SOX2 在维持人类胚胎干细胞多能性中的作用。
Genes Cells. 2010 May;15(5):455-70. doi: 10.1111/j.1365-2443.2010.01400.x. Epub 2010 Apr 9.
9
Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells.Tgif1 可平衡小鼠胚胎干细胞中核心多能性因子的活性。
Cell Rep. 2015 Oct 6;13(1):52-60. doi: 10.1016/j.celrep.2015.08.067. Epub 2015 Sep 24.
10
[OCT4 and NANOG are the key genes in the system of pluripotency maintenance in mammalian cells].OCT4和NANOG是哺乳动物细胞多能性维持系统中的关键基因。
Genetika. 2008 Dec;44(12):1589-608.
引用本文的文献
1
Integrator promotes the association of TFIID and RNA polymerase II to maintain pluripotency during development.整合因子促进TFIID与RNA聚合酶II的结合，以在发育过程中维持多能性。
Mol Cell. 2025 Aug 7;85(15):2937-2955.e10. doi: 10.1016/j.molcel.2025.07.006.
2
Interaction and regulatory expression of Polycomb and NuRD complexes in mouse embryonic stem cell under PKC inhibition.蛋白激酶C抑制下小鼠胚胎干细胞中多梳蛋白和核小体重塑去乙酰化酶复合物的相互作用及调控表达
Sci Rep. 2025 Jul 26;15(1):27204. doi: 10.1038/s41598-025-12427-3.
3
ARID4B: An Orchestrator from Stem Cell Fate to Carcinogenesis.ARID4B：从干细胞命运到肿瘤发生的调控因子
Cells. 2025 Jun 10;14(12):872. doi: 10.3390/cells14120872.
4
Rescuing DNMT1 fails to fully reverse the molecular and functional repercussions of its loss in mouse embryonic stem cells.挽救DNA甲基转移酶1（DNMT1）并不能完全逆转其在小鼠胚胎干细胞中缺失所造成的分子和功能影响。
Nucleic Acids Res. 2025 Feb 8;53(4). doi: 10.1093/nar/gkaf130.
5
CFTR represses a PDX1 axis to govern pancreatic ductal cell fate.囊性纤维化跨膜传导调节因子（CFTR）抑制PDX1轴以调控胰腺导管细胞命运。
iScience. 2024 Nov 15;27(12):111393. doi: 10.1016/j.isci.2024.111393. eCollection 2024 Dec 20.
6
Redox heterogeneity in mouse embryonic stem cells individualizes cell fate decisions.氧化还原异质性使小鼠胚胎干细胞的细胞命运决定个体化。
Dev Cell. 2024 Aug 19;59(16):2118-2133.e8. doi: 10.1016/j.devcel.2024.07.008. Epub 2024 Aug 5.
7
Oct4 redox sensitivity potentiates reprogramming and differentiation.Oct4 的氧化还原敏感性增强了重编程和分化。
Genes Dev. 2024 May 21;38(7-8):308-321. doi: 10.1101/gad.351411.123.
8
HBO1 determines SMAD action in pluripotency and mesendoderm specification.HBO1 决定多能性和中胚层特化中的 SMAD 作用。
Nucleic Acids Res. 2024 May 22;52(9):4935-4949. doi: 10.1093/nar/gkae158.
9
Roles and Regulation of H3K4 Methylation During Mammalian Early Embryogenesis and Embryonic Stem Cell Differentiation.H3K4 甲基化在哺乳动物早期胚胎发生和胚胎干细胞分化过程中的作用和调控。
Adv Exp Med Biol. 2024;1470:73-96. doi: 10.1007/5584_2023_794.
10
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.USP7 通过其催化和非催化活性抑制小鼠胚胎干细胞中的谱系分化基因。
Sci Adv. 2023 May 19;9(20):eade3888. doi: 10.1126/sciadv.ade3888. Epub 2023 May 17.
本文引用的文献
1
The controversial role of the Polycomb group proteins in transcription and cancer: how much do we not understand Polycomb proteins?多梳蛋白家族在转录和癌症中的争议性作用：我们对多梳蛋白的了解有多少？
FEBS J. 2015 May;282(9):1703-22. doi: 10.1111/febs.13112. Epub 2014 Nov 11.
2
Role of PRC2-associated factors in stem cells and disease.PRC2相关因子在干细胞和疾病中的作用。
FEBS J. 2015 May;282(9):1723-35. doi: 10.1111/febs.13083. Epub 2014 Oct 25.
3
Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network.Gata6、Nanog和Erk信号通过一个三稳态调节网络控制内细胞团中的细胞命运。
Development. 2014 Oct;141(19):3637-48. doi: 10.1242/dev.109678. Epub 2014 Sep 10.
4
Nascent RNA interaction keeps PRC2 activity poised and in check.初生 RNA 相互作用使 PRC2 活性保持平衡和抑制。
Genes Dev. 2014 Sep 15;28(18):1983-8. doi: 10.1101/gad.247940.114. Epub 2014 Aug 28.
5
Gene silencing triggers polycomb repressive complex 2 recruitment to CpG islands genome wide.基因沉默引发多梳抑制复合物 2 全基因组募集到 CpG 岛。
Mol Cell. 2014 Aug 7;55(3):347-60. doi: 10.1016/j.molcel.2014.06.005. Epub 2014 Jul 3.
6
Long noncoding RNAs in cell-fate programming and reprogramming.细胞命运编程与重编程中的长链非编码RNA
Cell Stem Cell. 2014 Jun 5;14(6):752-61. doi: 10.1016/j.stem.2014.05.014.
7
Chromatin repressive complexes in stem cells, development, and cancer.染色质抑制复合物在干细胞、发育和癌症中的作用。
Cell Stem Cell. 2014 Jun 5;14(6):735-51. doi: 10.1016/j.stem.2014.05.006.
8
Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.变异的PRC1复合物依赖性H2A泛素化驱动PRC2募集和多梳结构域形成。
Cell. 2014 Jun 5;157(6):1445-1459. doi: 10.1016/j.cell.2014.05.004. Epub 2014 May 22.
9
Oct4 is required for lineage priming in the developing inner cell mass of the mouse blastocyst.Oct4 对于小鼠囊胚内细胞团的谱系起始是必需的。
Development. 2014 Mar;141(5):1001-10. doi: 10.1242/dev.096875. Epub 2014 Feb 6.
10
Zrf1 is required to establish and maintain neural progenitor identity.Zrf1 对于建立和维持神经祖细胞的特性是必需的。
Genes Dev. 2014 Jan 15;28(2):182-97. doi: 10.1101/gad.228510.113.
Zotero 插件