College of Nursing, Woosuk University, Wanju 55338, Korea.
National Cancer Control Institute, National Cancer Center, Goyang 10408, Korea.
Int J Environ Res Public Health. 2021 Jan 18;18(2):775. doi: 10.3390/ijerph18020775.
Background-Dyslipidemia is one of the prominent risk factors for cardiovascular disease, which is the leading cause of death worldwide. Dyslipidemia has various causes, including metabolic capacity, genetic problems, physical inactivity, and dietary habits. This study aimed to determine the association between dyslipidemia and exposure to heavy metals in adults. Methods-Using data from the seventh Korean National Health and Nutrition Examination Survey (2016-2017), 5345 participants aged ≥20 years who were tested for heavy metal levels were analyzed in this study. Multiple logistic regression was conducted to assess the factors affecting the prevalence of dyslipidemia. Results-The risks of dyslipidemia among all and male participants with mercury (Hg) levels of ≥2.75 μg/L (corresponding to the Korean average level) were 1.273 and 1.699 times higher than in those with levels of <2.75 μg/L, respectively. The factors that significantly affected the dyslipidemia risk were age, household income, body mass index, and subjective health status in both males and females. Conclusions-In adult males, exposure to Hg at higher-than-average levels was positively associated with dyslipidemia. These results provide a basis for targeted prevention strategies for dyslipidemia using lifestyle guidelines for reducing Hg exposure and healthy behavioral interventions.
血脂异常是心血管疾病的主要危险因素之一，也是全球范围内的主要死亡原因。血脂异常的原因有很多，包括代谢能力、遗传问题、身体活动不足和饮食习惯等。本研究旨在确定血脂异常与成年人接触重金属之间的关联。
本研究使用了 2016-2017 年第七次韩国国家健康和营养检查调查的数据，对 5345 名接受重金属水平检测的年龄≥20 岁的参与者进行了分析。采用多因素 logistic 回归分析评估了影响血脂异常患病率的因素。
所有参与者和男性参与者中汞（Hg）水平≥2.75μg/L（相当于韩国的平均水平）的血脂异常风险分别是 Hg 水平<2.75μg/L 的参与者的 1.273 倍和 1.699 倍。在男性和女性中，显著影响血脂异常风险的因素是年龄、家庭收入、体重指数和主观健康状况。
在成年男性中，高于平均水平的 Hg 暴露与血脂异常呈正相关。这些结果为通过减少 Hg 暴露的生活方式指南和健康行为干预措施，针对血脂异常制定有针对性的预防策略提供了依据。
