Electrochemistry and Optical Spectroscopy Center of Excellence, Department of Chemistry, Faculty of Science, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand.
Department of Chemistry, Keio University, 3-14-1 Hiyoshi, Yokohama 223-8522, Japan.
Biosens Bioelectron. 2017 Dec 15;98:76-82. doi: 10.1016/j.bios.2017.06.034. Epub 2017 Jun 17.
The enormous demand for medical diagnostics has encouraged the fabrication of high- performance sensing platforms for the detection of glucose. Nonenzymatic glucose sensors are coming ever closer to being used in practical applications. Bimetallic catalysts have been shown to be superior to single metal catalysts in that they have greater activity and selectivity. Here, we demonstrate the preparation, characterization, and electrocatalytic characteristics of a new bimetallic Pt/Au nanocatalyst. This nanocatalyst can easily be synthesized by electrodeposition by sequentially depositing Au and Pt on the surface of a boron-doped diamond (BDD) electrode. We characterized the nanocatalyst by scanning electron microscopy (SEM), X-ray diffraction (XRD), and voltammetry. The morphology and composition of the nanocatalyst can be easily controlled by adjusting the electrodeposition process and the molar ratio between the Pt and Au precursors. The electrocatalytic characteristics of a Pt/Au/BDD electrode for the nonenzymatic oxidation of glucose were systematically investigated by cyclic voltammetry. The electrode exhibits higher catalytic activity for glucose oxidation than Pt/BDD and Au/BDD electrodes. The best catalytic activity and stability was obtained with a Pt:Au molar ratio of 50:50. Moreover, the presence of Au can significantly enhance the long-term stability and poisoning tolerance during the electro-oxidation of glucose. Measurements of glucose using the Pt/Au/BDD electrode were linear in the range from 0.01 to 7.5mM, with a detection limit of 0.0077mM glucose. The proposed electrode performs selective electrochemical analysis of glucose in the presence of common interfering species (e.g., acetaminophen, uric and ascorbic acids), avoiding the generation of overlapping signals from such species.
对医学诊断的巨大需求促使人们制造高性能的传感平台来检测葡萄糖。非酶葡萄糖传感器越来越接近实际应用。双金属催化剂在活性和选择性方面优于单金属催化剂。在这里，我们展示了一种新型双金属 Pt/Au 纳米催化剂的制备、表征和电催化特性。这种纳米催化剂可以通过在硼掺杂金刚石（BDD）电极表面依次沉积 Au 和 Pt 来通过电沉积轻松合成。我们通过扫描电子显微镜（SEM）、X 射线衍射（XRD）和伏安法对纳米催化剂进行了表征。通过调整电沉积过程和 Pt 和 Au 前体之间的摩尔比，可以轻松控制纳米催化剂的形态和组成。通过循环伏安法系统研究了 Pt/Au/BDD 电极对葡萄糖非酶氧化的电催化特性。与 Pt/BDD 和 Au/BDD 电极相比，该电极对葡萄糖氧化具有更高的催化活性。Pt:Au 摩尔比为 50:50 时获得最佳的催化活性和稳定性。此外，Au 的存在可以显著提高葡萄糖电氧化过程中的长期稳定性和抗中毒能力。使用 Pt/Au/BDD 电极测量葡萄糖的范围为 0.01 至 7.5mM，检测限为 0.0077mM 葡萄糖。在存在常见干扰物质（如对乙酰氨基酚、尿酸和抗坏血酸）的情况下，该电极对葡萄糖进行选择性电化学分析，避免了这些物质产生重叠信号。
