Jurick Sarah M, Weissberger Gali H, Clark Lindsay R, Wierenga Christina E, Chang Yu-Ling, Schiehser Dawn M, Han S Duke, Jak Amy J, Dev Sheena I, Bondi Mark W
San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120, USA.
VA San Diego Healthcare System, Research Service, San Diego, CA 92161, USA.
Arch Clin Neuropsychol. 2018 Mar 1;33(2):168-183. doi: 10.1093/arclin/acx056.
We examined BOLD (Blood-Oxygen-Level Dependent) activity reduction upon stimuli repetition of face-name pairs in older adults with amnestic (aMCI) and non-amnestic (naMCI) mild cognitive impairment diagnosed using a comprehensive actuarial method, and relationships between activity reduction and behavioral indices.
Twenty-nine cognitively healthy older adults (CHs) and 20 with MCI (n = 12 aMCI; n = 8 naMCI) underwent functional MRI event-related imaging, a comprehensive neuropsychological battery, and 1-year follow-up exam. During scanning, participants were shown face-name pairs 1-3 times and administered a post-scan recognition task.
The MCI group demonstrated less activity reduction upon repetition of face-name pairs within the MTL and other regions compared to CHs. Less activity reduction was associated with poorer Time 1 neuropsychological performance for the CH group and poorer post-scan recognition performance for the MCI group. Less activity reduction was related to poorer neuropsychological performance at Time 2 in the MCI group. Within MCIs, those with aMCI demonstrated less activity reduction upon repetition of face-name pairs than those with naMCI.
Distinct patterns of brain activity were identified in the MCI group compared to CHs, and aMCI compared to naMCI. Activated regions were not restricted to traditional memory circuitry, implicating a wider network of regions involved in the encoding of associative tasks. Findings add support to the hypothesis that lack of reduced BOLD activity reflects "faulty adaptation" to repeated stimuli and that reduction in activity represents successful encoding processes. They also provide further support for use of the face-name paradigm as a marker of prodromal Alzheimer's disease, and method to distinguish between MCI subtypes.
我们使用综合精算方法，研究了被诊断为遗忘型（aMCI）和非遗忘型（naMCI）轻度认知障碍的老年人在重复呈现面孔 - 名字对刺激时的血氧水平依赖（BOLD）活动减少情况，以及活动减少与行为指标之间的关系。
29名认知健康的老年人（CHs）和20名患有MCI的老年人（n = 12 aMCI；n = 8 naMCI）接受了功能磁共振成像事件相关成像、全面的神经心理测试组以及为期1年的随访检查。在扫描过程中，向参与者展示面孔 - 名字对1 - 3次，并进行扫描后识别任务。
与CHs相比，MCI组在重复呈现面孔 - 名字对时，内侧颞叶（MTL）和其他区域的活动减少较少。活动减少较少与CH组在时间1的神经心理表现较差以及MCI组扫描后识别表现较差相关。活动减少较少与MCI组在时间2的神经心理表现较差有关。在MCI患者中，aMCI患者在重复呈现面孔 - 名字对时的活动减少比naMCI患者少。
与CHs相比，MCI组以及与naMCI相比，aMCI组呈现出不同的脑活动模式。激活区域并不局限于传统记忆回路，这表明参与联想任务编码的区域网络更广泛。研究结果支持了以下假设：BOLD活动缺乏减少反映了对重复刺激的“错误适应”，而活动减少代表了成功的编码过程。它们还为使用面孔 - 名字范式作为前驱性阿尔茨海默病的标志物以及区分MCI亚型的方法提供了进一步支持。
