Nutu Oana Anisa, Marcacuzco Quinto Alberto A, Manrique Municio Alejandro, Justo Alonso Iago, Calvo Pulido Jorge, García-Conde María, Cambra Molero Félix, Jiménez Romero Luis Carlos
Servicio de Cirugía General y Aparato Digestivo, Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante de Órganos Abdominales, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España.
Servicio de Cirugía General y Aparato Digestivo, Unidad de Cirugía Hepato-Bilio-Pancreática y Trasplante de Órganos Abdominales, Hospital Universitario 12 de Octubre, Universidad Complutense de Madrid, Madrid, España.
Cir Esp. 2017 Jun-Jul;95(6):321-327. doi: 10.1016/j.ciresp.2017.05.008. Epub 2017 Jun 24.
Mucinous tumors of the appendix are a rare pathology, with a prevalence below 0.5%. Clinical presentation usually occurs during the sixth decade of life, and mucinous tumors can clinically mimic acute appendicitis. The aim of this study is to describe the clinical and demographic variables, therapeutic procedure and diagnosis of these tumors. We analyze the association between mucinous tumors and pseudomyxoma peritonei (PP), as well as the association with colorectal and ovarian tumors.
A retrospective study was performed including patients who underwent an appendectomy between December 2003 and December 2014.
Seventy-two mucinous tumors of the appendix were identified among 7.717 patients reviewed, resulting in a prevalence of 0.9%. Mean age at presentation was 64 years, 62% patients were female and 38% males. An incidental diagnosis was made in 43% of patients. Mucinous tumors of low malignant potential were significantly related to the presence of pseudomyxoma peritonei, identified in 16 (22%) of the cases. We also observed an increased risk of ovarian mucinous tumors in patients with a diagnosis of appendiceal mucinous neoplasm. In our sample, 22 (30.5%) patients showed a synchronous or metachronous colorectal cancer.
Appendiceal mucinous tumors are frequently an incidental finding. The diagnosis of mucinous tumors of low malignant potential is a factor associated with the development of pseudomyxoma peritonei. Histologic tumor grade and the presence of peritoneal dissemination will determine surgical treatment that can vary, from appendectomy to cytoreductive surgery.
阑尾黏液性肿瘤是一种罕见的病理类型，患病率低于0.5%。临床表现通常出现在生命的第六个十年，黏液性肿瘤在临床上可模仿急性阑尾炎。本研究的目的是描述这些肿瘤的临床和人口统计学变量、治疗方法及诊断。我们分析了黏液性肿瘤与腹膜假黏液瘤（PP）之间的关联，以及与结直肠和卵巢肿瘤的关联。
进行一项回顾性研究，纳入2003年12月至2014年12月期间接受阑尾切除术的患者。
在7717例接受检查的患者中，共识别出72例阑尾黏液性肿瘤，患病率为0.9%。出现症状时的平均年龄为64岁，62%的患者为女性，38%为男性。43%的患者为偶然诊断。低恶性潜能黏液性肿瘤与腹膜假黏液瘤的存在显著相关，16例（22%）病例中发现了这种情况。我们还观察到，诊断为阑尾黏液性肿瘤的患者发生卵巢黏液性肿瘤的风险增加。在我们的样本中，22例（30.5%）患者出现了同步或异时性结直肠癌。
阑尾黏液性肿瘤常为偶然发现。低恶性潜能黏液性肿瘤的诊断是与腹膜假黏液瘤发生相关的一个因素。组织学肿瘤分级和腹膜播散情况将决定手术治疗方式，从阑尾切除术到减瘤手术不等。
