Department of Surgery and Liver Transplant Institute, İnönü University School of Medicine, Malatya, Turkey.
Department of Pathology, İnönü University School of Medicine, Malatya, Turkey.
Turk J Gastroenterol. 2020 Sep;31(9):649-657. doi: 10.5152/tjg.2020.20537.
BACKGROUND/AIMS: To analysis the appendiceal mucinous lesions according to the World Health Organization (WHO) 2019 classification of tumors of the digestive system (non-neuroendocrine tumors of the appendix vermiformis)
Clinical and histopathological data of 37 patients with histopathologically proven appendiceal mucinous lesion from January 2010 to May 2019 were evaluated retrospectively. Pathology slides were re-evaluated by two pathologists according to the WHO 2019 classification of tumors of the digestive system.
Totally 37 patients (male:19 female: 18) aged 23 to 93 years were analyzed. Majority of the patients (75.7 %) had underwent appendectomy due to preliminary diagnosis of acute appendicitis (n=22) or periappendiceal tumoral lesions (n=9), the others (n=9) underwent incidental appendectomy. Whereas acute appendicitis was histopathologically diagnosed in 16 (43.2%) patients, perforation was diagnosed in 12 (32.4%) patients (perforation without appendicitis=3, perforation with appendicitis=6). According to the initial, pathology reports were prepared as follows: mucocele (n=10), mucinous cystadenoma (n=9), low-grade mucinous neoplasm (n=6), mucinous adenocarcinoma (n=5), mucosal hyperplasia (n=5), hyperplastic polyp (n=1), adenomatous polyp (n=1). On the basis of the WHO 2019 classification, pathology reports were prepared as follows: low-grade mucinous neoplasm (n=17), simple retention cysts (n=6), hyperplastic polyp (n=6), mucinous adenocarcinoma (n=5), ruptured appendiceal diverticula (n=2), sessile serrated lesion (n=1).
The term of appendiceal mucinous lesion, which is recently introduced into medical literature is suitable to distinguish between lesions with and without malignancy potential. The WHO 2019 classification system has been an important step in simplifying the classification of non- neuroendocrine tumors of the appendix vermiformis.
背景/目的：根据世界卫生组织（WHO）2019 年消化系统肿瘤分类（阑尾非神经内分泌肿瘤）对阑尾黏液性病变进行分析。
回顾性分析 2010 年 1 月至 2019 年 5 月 37 例经组织病理学证实的阑尾黏液性病变患者的临床和组织病理学资料。根据 WHO 2019 年消化系统肿瘤分类，由两位病理学家对病理切片进行重新评估。
共分析了 37 例患者（男 19 例，女 18 例），年龄 23 至 93 岁。大多数患者（75.7%）因初步诊断为急性阑尾炎（n=22）或阑尾周围肿瘤性病变（n=9）行阑尾切除术，其余 9 例（n=9）行偶然阑尾切除术。16 例（43.2%）患者病理诊断为急性阑尾炎，12 例（32.4%）患者诊断为穿孔（无阑尾炎穿孔=3 例，阑尾炎穿孔=6 例）。根据初始病理报告，准备如下：黏液囊肿（n=10）、黏液囊腺瘤（n=9）、低级别黏液性肿瘤（n=6）、黏液性腺癌（n=5）、黏膜增生（n=5）、增生性息肉（n=1）、腺瘤性息肉（n=1）。根据 WHO 2019 年分类，病理报告如下：低级别黏液性肿瘤（n=17）、单纯潴留囊肿（n=6）、增生性息肉（n=6）、黏液性腺癌（n=5）、阑尾憩室破裂（n=2）、无蒂锯齿状病变（n=1）。
阑尾黏液性病变这一最近引入医学文献的术语，适合于区分具有和不具有恶性潜能的病变。WHO 2019 年分类系统是简化阑尾非神经内分泌肿瘤分类的重要一步。
