Maslovara Sinisa, Butkovic Soldo Silva, Sestak Anamarija, Milinkovic Katarina, Rogic-Namacinski Jasna, Soldo Anamarija
County General Hospital, Department of Otolaryngology, Vukovar, Croatia; University of Osijek, Medical Faculty, Department of Otorhinolaryngology and Maxillofacial Surgery, Osijek, Croatia.
Clinical Hospital Center, Department of Neurology, Osijek, Croatia; University of Osijek, Medical Faculty, Department of Neurology, Osijek, Croatia.
Braz J Otorhinolaryngol. 2018 Jul-Aug;84(4):453-459. doi: 10.1016/j.bjorl.2017.05.007. Epub 2017 Jun 11.
Benign paroxysmal positional vertigo is the most common cause of dizziness in the general population. It is a condition with potential impact of reduced levels of vitamin D on its recurrent attacks.
The aim of this study was to measure the serum levels of 25-hydroxyvitamin D3 (25-OH D3) in patients with benign paroxysmal positional vertigo and determine whether there is a difference in the serum levels of vitamin D3 between patients with and without recurrence, as well as between the different clinical forms of benign paroxysmal positional vertigo.
The study included 40 patients who came to the regular medical examination, diagnosed with posterior canal-benign paroxysmal positional vertigo based on the positive Dix-Hallpike's test. All patients underwent Epley manoeuvre after the diagnosis. Patients were classified according to current guidelines for levels of vitamin D3 in the serum in three groups: the deficiency, insufficiency and adequate level.
The average serum level of 25-OH D3 among respondents was 20.78ng/mL, indicating a lack or insufficiency of the aforementioned 25-OH D3. According to the levels of 25-OH D3, most patients suffer from deficiency (47.5%). 7 (17.5%) respondents had adequate blood level of 25-OH D3, and 14 (35%) respondents suffer from insufficiency. A significant difference was not found in the serum level of 25-OH D3 between patients with and without benign paroxysmal positional vertigo recurrence. There was a significant difference in the serum levels of 25-OH D3 in comparison to the clinical form of the disease. Lower 25-OH D3 values were found in patients with canalithiasis compared to those with cupulolithiasis.
There were no significant differences in the vitamin D3 serum level in patients with and without recurrence. The study showed a low level of serum vitamin D3 in most patients, indicating the need for supplemental therapy.
良性阵发性位置性眩晕是普通人群中头晕最常见的原因。这是一种维生素D水平降低可能对其反复发作产生影响的病症。
本研究的目的是测量良性阵发性位置性眩晕患者血清中25-羟基维生素D3（25-OH D3）的水平，并确定复发患者与未复发患者之间以及不同临床类型的良性阵发性位置性眩晕患者之间血清维生素D3水平是否存在差异。
该研究纳入了40名前来定期体检的患者，这些患者根据Dix-Hallpike试验阳性被诊断为后半规管良性阵发性位置性眩晕。所有患者在诊断后均接受了Epley手法复位。根据目前血清维生素D3水平指南，将患者分为三组：缺乏、不足和充足水平。
受访者的平均血清25-OH D3水平为20.78ng/mL，表明上述25-OH D3缺乏或不足。根据25-OH D3水平，大多数患者存在缺乏（47.5%）。7名（17.5%）受访者的25-OH D3血液水平充足，14名（35%）受访者存在不足。良性阵发性位置性眩晕复发患者与未复发患者之间的血清25-OH D3水平未发现显著差异。与疾病的临床类型相比，血清25-OH D3水平存在显著差异。与嵴顶结石症患者相比，管结石症患者的25-OH D3值更低。
复发患者与未复发患者的维生素D3血清水平无显著差异。研究表明大多数患者的血清维生素D3水平较低，表明需要补充治疗。
