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严重蝎蜇伤:病理生理学及炎症在多器官功能衰竭中的作用

Severe scorpion envenomation: pathophysiology and the role of inflammation in multiple organ failure.

作者信息

Bahloul M, Regaieg K, Chabchoub I, Kammoun M, Chtara K, Bouaziz M

机构信息

Hôpital Habib Bourguiba, service de réanimation médicale, route El Ain Km 1, 3029 Sfax, Tunisie.

Hôpital Hedi Chaker, service de pédiatrie générale, route El Ain Km 1, 3029 Sfax, Tunisie.

出版信息

Med Sante Trop. 2017 Jun 1;27(2):214-221. doi: 10.1684/mst.2017.0688.

DOI:10.1684/mst.2017.0688
PMID:28655685
Abstract

Scorpion stings occur on every continent except Antarctica. The correlation between young age and severity of clinical manifestations after this envenomation is well-established. Several studies have emphasized the relevance of pro-inflammatory mediators in the pathophysiological manifestations of human scorpion envenomation. Moreover, there is a significant association between pro-inflammatory cytokine levels in the blood and the severity of scorpion envenomation. Release of these cytokines increases the severity of the visceral damage induced by the direct action of the venom and the activation of both the sympathetic and parasympathetic nervous systems.

摘要

除南极洲外,蝎子蜇伤在各大洲均有发生。蝎子蜇伤后,年龄与临床表现严重程度之间的相关性已得到充分证实。多项研究强调了促炎介质在人类蝎子蜇伤病理生理表现中的相关性。此外,血液中促炎细胞因子水平与蝎子蜇伤的严重程度之间存在显著关联。这些细胞因子的释放会增加毒液直接作用以及交感和副交感神经系统激活所导致的内脏损伤的严重程度。

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Toxins (Basel). 2024 May 4;16(5):214. doi: 10.3390/toxins16050214.
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Am J Cardiovasc Dis. 2023 Dec 15;13(6):354-362. eCollection 2023.
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