Hajjaj-Hassouni Najia, Mawani Nada, Allali Fadoua, Rkain Hanan, Hassouni Kenza, Hmamouchi Ihsane, Dougados Maxime
LIRPOS-URAC30, Faculty of Medicine and Pharmacy, Mohammed V University, Rabat, Morocco.
Department of Rheumatology, El Ayachi Hospital, Ibn Sina University Hospital, Rabat-Salé, Morocco.
Int J Rheumatol. 2017;2017:5491676. doi: 10.1155/2017/5491676. Epub 2017 Jun 1.
The aims of this study are to evaluate vitamin D status in 1413 RA patients of COMORA study from 15 countries and to analyze relationship between patients' RA characteristics and low levels of vitamin D. All demographic, clinical, and biological data and RA comorbidities were completed. The results showed that the average of vitamin D serum dosage was 27.3 ng/mL ± 15.1 [0.1-151]. Status of vitamin D was insufficient in 54.6% and deficient in 8.5% of patients. 43% of RA patients were supplemented with vitamin D and absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency ( < 0.001). Finally, our study shows that the status of low levels of vitamin D is common in RA in different countries and under different latitudes. Absence of supplementation on vitamin D was related to higher prevalence of vitamin D deficiency. Low levels of vitamin D were associated with patients characteristics (age, BMI, and educational level), RA (disease activity and corticosteroid dosage), and comorbidities (lung disease and osteoporosis therapy). This suggests the need for a particular therapeutic strategy to improve vitamin D status in RA patients.
本研究的目的是评估来自15个国家的1413名参加COMORA研究的类风湿关节炎（RA）患者的维生素D状况，并分析患者的RA特征与低水平维生素D之间的关系。所有人口统计学、临床和生物学数据以及RA合并症均已完善。结果显示，维生素D血清剂量的平均值为27.3 ng/mL±15.1 [0.1 - 151]。54.6%的患者维生素D状况不足，8.5%的患者维生素D缺乏。43%的RA患者补充了维生素D，未补充维生素D与维生素D缺乏的较高患病率相关（<0.001）。最后，我们的研究表明，不同国家和不同纬度下，RA患者中维生素D水平低的状况很常见。未补充维生素D与维生素D缺乏的较高患病率相关。维生素D水平低与患者特征（年龄、体重指数和教育程度）、RA（疾病活动度和皮质类固醇剂量）以及合并症（肺部疾病和骨质疏松症治疗）有关。这表明需要一种特定的治疗策略来改善RA患者的维生素D状况。
