Ohta Tomoyuki, Nishioka Makiko, Nakata Norio, Fukuda Kunihiko, Shirakawa Takako
Department of Radiology, Diagnostic Ultrasound Center, Jikei University School of Medicine, 3-19-18 Nishi-Shinbashi, Minato-ku, Tokyo, 105-8471, Japan.
Department of Radiological Sciences, Tokyo Metropolitan University Graduate School of Human Health Sciences, Tokyo, Japan.
J Med Ultrason (2001). 2018 Jan;45(1):81-87. doi: 10.1007/s10396-017-0804-7. Epub 2017 Jun 27.
The incidences of perithyroidal lymph nodes (PTLNs) in benign thyroid diseases were investigated.
A total of 108 patients were divided into 36 with benign thyroid nodules, 33 with Hashimoto's thyroiditis, 14 with Graves' disease, 10 with hypothyroidism of undetermined etiology, nine with silent thyroiditis, and six with subacute thyroiditis. We assessed the relationships among PTLNs and these groups, thyroid volume, thyroid parenchyma echogenicity, and anti-thyroid-stimulating hormone receptor, anti-thyroglobulin, and anti-thyroid peroxidase antibodies (TRAb, TgAb, and TPOAb).
The PTLN-positive rates in Hashimoto's thyroiditis (69.7%), subacute thyroiditis (83.8%), silent thyroiditis (77.8%), and Graves' disease (35.7%) groups were significantly higher than those in benign thyroid nodules (5.6%) and hypothyroidism of unknown etiology (0%) groups. The PTLN-positive rates were significantly higher in cases with TgAb and/or TPOAb (P < 0.01) and in those with lower parenchyma echogenicity (P < 0.01).
PTLNs were seen in inflammatory thyroid diseases, but were rarely detected in other thyroid diseases. These findings indicate that PTLNs are an indicator for differentiating inflammation of the thyroid. Lower echogenicity of the thyroid, known to correspond to inflammation, showed a correlation with the positive rate of PTLNs. PTLNs in cases of Graves' disease may be due to coexisting thyroiditis related to TgAb and/or TPOAb.
研究良性甲状腺疾病中甲状腺周围淋巴结（PTLNs）的发生率。
总共108例患者被分为36例患有良性甲状腺结节、33例患有桥本甲状腺炎、14例患有格雷夫斯病、10例患有病因不明的甲状腺功能减退症、9例患有寂静性甲状腺炎以及6例患有亚急性甲状腺炎。我们评估了PTLNs与这些组、甲状腺体积、甲状腺实质回声以及抗促甲状腺激素受体、抗甲状腺球蛋白和抗甲状腺过氧化物酶抗体（TRAb、TgAb和TPOAb）之间的关系。
桥本甲状腺炎组（69.7%）、亚急性甲状腺炎组（83.8%）、寂静性甲状腺炎组（77.8%）和格雷夫斯病组（35.7%）的PTLN阳性率显著高于良性甲状腺结节组（5.6%）和病因不明的甲状腺功能减退症组（0%）。TgAb和/或TPOAb阳性的病例以及实质回声较低的病例的PTLN阳性率显著更高（P<0.01）。
PTLNs见于甲状腺炎性疾病，但在其他甲状腺疾病中很少检测到。这些发现表明PTLNs是区分甲状腺炎症的一个指标。已知与炎症相对应的甲状腺低回声与PTLNs的阳性率相关。格雷夫斯病病例中的PTLNs可能归因于与TgAb和/或TPOAb相关的并存甲状腺炎。
