Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
Cell Microbiol. 2017 Oct;19(10). doi: 10.1111/cmi.12762. Epub 2017 Jul 21.
Listeria monocytogenes, the causative agent of listeriosis, is an intracellular pathogen that is exquisitely evolved to survive and replicate in the cytosol of eukaryotic cells. Eukaryotic cells typically restrict bacteria from colonising the cytosol, likely through a combination of cell autonomous defences, nutritional immunity, and innate immune responses including induction of programmed cell death. This suggests that L. monocytogenes and other professional cytosolic pathogens possess unique metabolic adaptations, not only to support replication but also to facilitate resistance to host-derived stresses/defences and avoidance of innate immune activation. In this review, we outline our current understanding of L. monocytogenes metabolism in the host cytosol and highlight major metabolic processes which promote intracellular replication and survival.
产单核细胞李斯特菌是李斯特菌病的病原体，是一种高度进化的细胞内病原体，能够在真核细胞的细胞质中生存和复制。真核细胞通常通过细胞自主防御、营养免疫以及包括程序性细胞死亡诱导在内的先天免疫反应来限制细菌在细胞质中的定植。这表明，产单核细胞李斯特菌和其他专业的细胞质病原体具有独特的代谢适应性，不仅可以支持复制，还可以促进对宿主来源的应激/防御的抵抗和避免先天免疫激活。在这篇综述中，我们概述了我们目前对产单核细胞李斯特菌在宿主细胞质中的代谢的理解，并强调了促进细胞内复制和存活的主要代谢过程。
