中国野生啮齿动物和鼠兔中存在两种具有不同毒力的流行亚种克隆菌株。

Two Prevalent subsp Clonal Strains With Different Virulence Exist in Wild Rodents and Pikas of China.

作者信息

Gan Lin, Mao Pan, Jiang Huaying, Zhang Lu, Liu Dongxin, Cao Xiaolong, Wang Yan, Wang Yiqian, Sun Hui, Huang Ying, Ye Changyun

机构信息

State Key Laboratory for Infectious Disease Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Hunan Provincial Key Laboratory for Special Pathogens, Institute of Pathogenic Biology, Medical College, University of South China, Hengyang, China.

出版信息

Front Vet Sci. 2020 Feb 26;7:88. doi: 10.3389/fvets.2020.00088. eCollection 2020.

subsp. is an intracellular bacterium distributed widely in nature, causing the listeriosis in ruminants and humans. Previous researches had isolated 116 strains of subsp. from wild rodents and pikas of different regions in China, and the predominant sequence types were ST1 and ST2. In this study, we first investigated the biological characteristics and virulence of these two clonal strains including motility, metabolism and virulence in cells and mouse model. The results demonstrated the ST1 strains exhibited motility, wide metabolic activity and hypervirulence, whereas the ST2 strains showed non-motility, relative lower metabolic activity and virulence. Considering the transmissible ability from wild rodents and pikas to ecological environment, the subsp. with potential pathogenicity to humans and ruminants should be monitored.