Yazicioglu O, Yaman B C, Güler A, Koray F
Department of Conservative Dentistry, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
Department of Conservative Dentistry, Faculty of Dentistry, Osmangazi University, Eskişehir, Turkey.
Niger J Clin Pract. 2017 Jun;20(6):686-692. doi: 10.4103/1119-3077.180073.
The aim of this in vivo study was to quantitatively evaluate the remineralization of the enamel caries on smooth and occlusal surfaces using DIAGNOdent, after daily application of casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP).
Thirty volunteers, aged 18-30 years, with white spot lesions on the smooth and occlusal surfaces of the teeth were included in the study. These white spot lesions were visually examined and the degree of demineralization was quantitatively evaluated using DIAGNOdent. Volunteers with lesions scored as enamel caries on smooth surfaces (n = 109) and on occlusal surfaces (n = 176) were randomly divided into control and study groups. Both groups were instructed regarding oral hygiene and were asked to brush their teeth with the same tooth paste and tooth brush. In the study group, CPP-ACFP was applied daily for 4 min on the existing enamel caries lesions. After 4 weeks, the mineralization changes in enamel caries on the smooth and occlusal surfaces were assessed by DIAGNOdent. Recorded data were statistically analyzed by Wilcoxon signed-rank test and Mann-Whitney U-test.
Comparison of DIAGNOdent values evaluated before and after the application of CPP-ACFP showed that the remineralization of enamel caries lesions on smooth and occlusal surfaces occurred in the study group (both, P < 0.001). The control group showed no quantitative changes at the end of 4 weeks (P > 0.05). At the end of the study period, the DIAGNOdent values differed significantly between the control and study groups (P < 0.001).
Daily local application of CPP-ACFP for 4 min for 4 weeks results in significant remineralization of the initial caries lesions.
CPP-ACFP can be used in the treatment of white spot lesions.
本体内研究的目的是在每日应用酪蛋白磷酸肽 - 无定形氟化钙磷酸盐（CPP - ACFP）后，使用DIAGNOdent定量评估光滑面和咬合面釉质龋的再矿化情况。
本研究纳入了30名年龄在18至30岁之间、牙齿光滑面和咬合面有白斑病变的志愿者。对这些白斑病变进行肉眼检查，并使用DIAGNOdent定量评估脱矿程度。将光滑面（n = 109）和咬合面（n = 176）有病变且被评为釉质龋的志愿者随机分为对照组和研究组。两组均接受口腔卫生指导，并要求使用相同的牙膏和牙刷刷牙。在研究组中，每天在现有的釉质龋病变上应用CPP - ACFP 4分钟。4周后，通过DIAGNOdent评估光滑面和咬合面釉质龋的矿化变化。记录的数据采用Wilcoxon符号秩检验和Mann - Whitney U检验进行统计学分析。
比较应用CPP - ACFP前后的DIAGNOdent值表明，研究组光滑面和咬合面的釉质龋病变均发生了再矿化（两者，P < 0.001）。对照组在4周结束时未显示出定量变化（P > 0.05）。在研究期结束时，对照组和研究组的DIAGNOdent值差异显著（P < 0.001）。
每天局部应用CPP - ACFP 4分钟，持续4周可使初始龋病变显著再矿化。
CPP - ACFP可用于治疗白斑病变。
