Baafif Hussain A, Alibrahim Ibrahim F, Alotaibi Sami H, Alharbi Hatem G, Shubaily Meshal N, Elkwatehy Wahdan M A
Faculty of Dentistry, Umm AlQura University, Mansoura, Egypt.
Dental Public Health and Preventive Dentistry, Faculty of Dentistry, Umm Al-Qura University, KSA and Faculty of Dentistry, Mansoura University, Mansoura, Egypt.
J Int Soc Prev Community Dent. 2020 Aug 6;10(4):438-444. doi: 10.4103/jispcd.JISPCD_483_19. eCollection 2020 Jul-Aug.
White spot lesions (WSLs) are considered as the first sign of the progression of dental caries that can be reversed. Casein phosphopeptide-amorphous calcium fluoride phosphate (CPP-ACFP) varnish can promote remineralization process of the demineralized tooth structure. Also, WSLs can be managed by using caries infiltrant (ICON), which infiltrates etched enamel surface of the WSLs.
The main aim was to evaluate and compare the efficacy of ICON versus CPP-ACFP varnish to treat WSLs in the same oral environments.
A total of 30 participants aged 20-40 years with at least two WSLs have participated in this trial. Split-mouth technique has been used in this trial where WSLs on the left side have been treated with ICON, whereas WSLs on the right side have been treated with CPP-ACFP varnish. Clinical evaluation using DIAGNOdent was carried out at baseline, 1 week, 1, 3, 6, and 12 months after application to determine the effectiveness of these materials in treating WSLs.
Significant differences were observed between all follow-up DIAGNOdent scores compared to baseline readings of both ICON and CPP-ACFP ( = 0.000 for all comparisons). Statistically significant differences were observed between DIAGNOdent scores of ICON compared to CPP-ACFP at all follow-up intervals ( = 0.006, 0.008, 0.045, 0.036, and 0.000).
Both ICON and CPP-ACFP were effective in the treatment of WSLs of smooth surfaces but the efficacy of CPP-ACFP was better than ICON.
白斑病变（WSLs）被认为是龋齿进展的首个迹象，且这种情况是可以逆转的。酪蛋白磷酸肽 - 无定形氟化钙磷酸盐（CPP - ACFP）清漆可促进脱矿牙结构的再矿化过程。此外，白斑病变可通过使用龋病渗透剂（ICON）来处理，该渗透剂可渗透到白斑病变的酸蚀釉质表面。
主要目的是评估和比较在相同口腔环境下，ICON与CPP - ACFP清漆治疗白斑病变的疗效。
共有30名年龄在20 - 40岁、至少有两处白斑病变的参与者参加了本试验。本试验采用了半口对照技术，左侧的白斑病变用ICON治疗，而右侧的白斑病变用CPP - ACFP清漆治疗。在应用后的基线、1周、1、3、6和12个月使用DIAGNOdent进行临床评估，以确定这些材料治疗白斑病变的有效性。
与ICON和CPP - ACFP的基线读数相比，所有随访的DIAGNOdent评分均观察到显著差异（所有比较 = 0.000）。在所有随访间隔中，ICON与CPP - ACFP的DIAGNOdent评分之间均观察到统计学上的显著差异（ = 0.006、0.008、0.045、0.036和0.000）。
ICON和CPP - ACFP在治疗光滑表面的白斑病变方面均有效，但CPP - ACFP的疗效优于ICON。
