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亚临床甲状腺功能减退中出现的肾功能障碍——甲状腺素的可能作用。

Renal dysfunction manifesting in subclinical hypothyroidism-a possible role for thyroxine.

作者信息

Asim Muhammad, El Esnawi Mohammad

机构信息

Nephrology Section, Department of Medicine, Hamad Medical Corporation, Doha, Qatar.

出版信息

NDT Plus. 2010 Jun;3(3):282-284. doi: 10.1093/ndtplus/sfq020. Epub 2010 Mar 12.

DOI:10.1093/ndtplus/sfq020
PMID:28657047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5477955/
Abstract

Renal dysfunction, both acute and chronic, is a recognized association of hypothyroidism. We describe a patient who developed renal dysfunction at the stage of hypothyroidism. We emphasize that renal dysfunction is a reflection of tissue hypothyroidism, dissociated with the severity of biochemical hypothyroidism and can manifest in patients with subclinical hypothyroidism. This report also makes a case for thyroxine therapy if an alternative cause of renal dysfunction is not found in a patient with subclinical hypothyroidism.

摘要

急慢性肾功能不全均是公认的甲状腺功能减退症的相关病症。我们描述了一名在甲状腺功能减退阶段出现肾功能不全的患者。我们强调,肾功能不全是组织甲状腺功能减退的一种表现,与生化性甲状腺功能减退的严重程度无关,且可在亚临床甲状腺功能减退患者中出现。本报告还指出,如果在亚临床甲状腺功能减退患者中未发现肾功能不全的其他病因,则有必要进行甲状腺素治疗。

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本文引用的文献

1
Renal impairment resulting from hypothyroidism.甲状腺功能减退导致的肾功能损害。
NDT Plus. 2008 Dec;1(6):440-441. doi: 10.1093/ndtplus/sfn158. Epub 2008 Oct 13.
2
Subclinical hypothyroidism (SCH) is not associated with metabolic derangement, cognitive impairment, depression or poor quality of life (QoL) in elderly subjects.亚临床甲状腺功能减退症(SCH)与老年患者的代谢紊乱、认知障碍、抑郁或生活质量(QoL)下降无关。
Arch Gerontol Geriatr. 2010 May-Jun;50(3):e68-73. doi: 10.1016/j.archger.2009.05.015. Epub 2009 Jul 9.
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Kidney failure in the elderly due to hypothyroidism: a case report.老年人甲状腺功能减退所致肾衰竭:一例报告
Sao Paulo Med J. 2008 Sep;126(5):291-3. doi: 10.1590/s1516-31802008000500010.
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Clin Nephrol. 2007 Jun;67(6):391-3. doi: 10.5414/cnp67391.
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Reversible acute renal failure associated with hypothyroidism: report of four cases with a brief review of literature.与甲状腺功能减退相关的可逆性急性肾衰竭:4例报告并文献简要回顾
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Cardiovascular and atherogenic aspects of subclinical hypothyroidism.亚临床甲状腺功能减退的心血管及动脉粥样硬化相关方面
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Estimation of tissue hypothyroidism by a new clinical score: evaluation of patients with various grades of hypothyroidism and controls.通过一种新的临床评分评估组织甲状腺功能减退:对不同程度甲状腺功能减退患者及对照组的评估。
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8
Peripheral responses to thyroid hormone before and after L-thyroxine therapy in patients with subclinical hypothyroidism.亚临床甲状腺功能减退患者左甲状腺素治疗前后甲状腺激素的外周反应。
J Clin Endocrinol Metab. 1981 Dec;53(6):1238-42. doi: 10.1210/jcem-53-6-1238.
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Left ventricular performance in subclinical hypothyroidism.
Q J Med. 1985 Dec;57(224):857-65.
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Thyroid hormone coordinately regulates Na+-K+-ATPase alpha- and beta-subunit mRNA levels in kidney.甲状腺激素协同调节肾脏中钠钾ATP酶α亚基和β亚基的mRNA水平。
Am J Physiol. 1988 Feb;254(2 Pt 1):C323-9. doi: 10.1152/ajpcell.1988.254.2.C323.