Quinlan J E, Davies J
Neurosci Lett. 1985 Sep 16;60(1):39-46. doi: 10.1016/0304-3940(85)90378-7.
Responses of rat cerebellar Purkinje cells to iontophoretically administered excitatory amino acids have been studied in vivo. Responses to N-methyl-D-aspartate (NMDA) were either biphasic (excitation followed by inhibition) or purely inhibitory and were antagonized by the selective NMDA-receptor antagonist, 2-amino-5-phosphonovalerate. Quisqualate and kainate either excited or induced biphasic responses, in these neurones, which were only reduced by amino acid antagonists that acted at non-NMDA receptors. The excitatory amino acid-induced inhibitions were also antagonized by the selective gamma-aminobutyric acid (GABA) antagonist, picrotoxin, suggesting that they were indirectly mediated via GABAergic inhibitory interneurones, which could be excited via NMDA and non-NMDA receptors.
已在体内研究了大鼠小脑浦肯野细胞对离子电渗法给予的兴奋性氨基酸的反应。对N-甲基-D-天冬氨酸（NMDA）的反应要么是双相的（兴奋后抑制），要么是纯粹的抑制性，并且被选择性NMDA受体拮抗剂2-氨基-5-磷酸戊酸所拮抗。在这些神经元中，quisqualate和海人藻酸要么引起兴奋，要么诱导双相反应，这些反应仅被作用于非NMDA受体的氨基酸拮抗剂所减弱。兴奋性氨基酸诱导的抑制作用也被选择性γ-氨基丁酸（GABA）拮抗剂印防己毒素所拮抗，这表明它们是通过GABA能抑制性中间神经元间接介导的，这些中间神经元可通过NMDA和非NMDA受体被激活。
