a Clinic of Cardiology , Balikligol State Hospital , Sanliurfa , Turkey.
b Department of Cardiology , Avrupa Medicine Center , Karabaglar , Izmir , Turkey.
Clin Exp Hypertens. 2017;39(7):680-684. doi: 10.1080/10641963.2017.1313855. Epub 2017 Jun 28.
Fragmented QRS (fQRS) has been shown to be associated with poor outcome in various cardiovascular diseases. Non-dipper hypertension is also associated with increased cardiovascular mortality. The aim of our study is to investigate the relationship between fQRS and non-dipper status in hypertensive patients without left ventricular hypertrophy (LVH).
This study included 106 hypertensive patients without LVH. Patients were divided into two groups: dipper hypertension and non-dipper hypertension. The presence of fQRS was analyzed from surface electrocardiography.
Frequency of fQRS (56% vs. 19.6%, p < 0.001) and mean number of leads with fQRS (1.9 ± 1.7 vs. 0.6 ± 1.0, p < 0.001) were significantly higher in patients with non-dipper hypertension compared to dipper hypertension. In addition, the number of leads with fQRS was positively correlated with systolic (r = 0.334, p < 0.001) and diastolic (r = 0.280, p = 0.004) blood pressures (BP). By a multivariate regression analysis, fQRS (OR: 5.207, 95% CI: 2.195-12.353, p < 0.001) was found to be independent predictor of non-dipper status.
fQRS is independent predictor of non-dipper status in hypertensive patients without LVH. Also, the higher number of leads with fQRS is associated with higher sleep systolic and diastolic BPs.
碎裂 QRS 波（fQRS）已被证明与各种心血管疾病的不良预后相关。非杓型高血压也与心血管死亡率增加相关。我们的研究目的是探讨无左心室肥厚（LVH）的高血压患者中 fQRS 与非杓型状态之间的关系。
这项研究纳入了 106 例无 LVH 的高血压患者。患者被分为两组：杓型高血压和非杓型高血压。从体表心电图分析 fQRS 的存在。
与杓型高血压相比，非杓型高血压患者 fQRS 的频率（56% vs. 19.6%，p < 0.001）和存在 fQRS 的导联平均数（1.9 ± 1.7 vs. 0.6 ± 1.0，p < 0.001）显著更高。此外，存在 fQRS 的导联数与收缩压（r = 0.334，p < 0.001）和舒张压（r = 0.280，p = 0.004）呈正相关。通过多变量回归分析，fQRS（OR：5.207，95%CI：2.195-12.353，p < 0.001）被发现是非杓型状态的独立预测因子。
fQRS 是无 LVH 的高血压患者非杓型状态的独立预测因子。此外，存在 fQRS 的导联数越多，与睡眠时收缩压和舒张压越高相关。
