Bazi Ali, Sharifi-Rad Javad, Rostami Daryoush, Sargazi-Aval Omolbanin, Safa Amin
Lecturer, Clinical Research Development Unit, Amir-Al-Momenin Hospital, Zabol University Medical Science, Zabol, Iran.
Research Scholar, Department of Biochemistry, Phytochemistry Research Scholar, Shahid Beheshti University of Medical Science, Tehran, Iran.
J Clin Diagn Res. 2017 May;11(5):BC01-BC04. doi: 10.7860/JCDR/2017/24762.9806. Epub 2017 May 1.
Diabetes Mellitus (DM) represents a major concern in Thalassaemia Major (TM) patients.
The present study was conducted to evaluate the frequency of Impaired Fasting Glucose (IFG) and DM in TM patients in Southeast of Iran.
Fasting Blood Glucose (FBS) was determined using fasting blood samples in 148 TM patients. Demographical data was collected by a questionnaire. Clinical and laboratory variables including cell blood counts, pre-transfusion Haemoglobin (Hb) level, and five-year ferritin were extracted from medical records. Statistical analysis was performed in SPSS19.0 software using chi-square, student t-test and logistic regression.
Females and males comprised 83 (56.1%) and 65 (43.9%) subjects respectively. The mean age and mean five-year ferritin were 17.3±6.1 year-old and 5060.6±2395 ng/ml respectively. Overall, 39 (26.4%) patients had IFG, while 13 (8.8%) were diagnosed with DM. Significant differences were identified in the mean age, volume of transfused blood per occasion, and mean five-years ferritin between the patients with IFG or DM and the patients with normal fasting glucose level. Patients with age >25-year-old had an increased risk of both IFG (OR=4.7,95% CI: 1.3-17, p=0.01) and DM (OR= 7.1, 95% CI: 1-49.2, p=0.04). In addition, splenectomized patients showed a higher risk for IFG (OR=4.3, 95% CI: 1.5-12.1, p=0.005), and ferritin value >6000 ng/ml were associated with an elevated risk of DM (OR=7, 95% CI: 0.8-60.1, p=0.07).
Our results indicated that higher age, mean five-years ferritin, volume of blood transfused per occasion, as well as splenectomy were risk factors of IFG and DM in TM patients.
糖尿病（DM）是重型地中海贫血（TM）患者的一个主要问题。
本研究旨在评估伊朗东南部TM患者中空腹血糖受损（IFG）和糖尿病的发生率。
采用空腹血样测定148例TM患者的空腹血糖（FBS）。通过问卷调查收集人口统计学数据。从病历中提取包括血细胞计数、输血前血红蛋白（Hb）水平和五年铁蛋白在内的临床和实验室变量。使用SPSS19.0软件进行卡方检验、学生t检验和逻辑回归分析。
女性和男性分别有83例（56.1%）和65例（43.9%）。平均年龄和平均五年铁蛋白分别为17.3±6.1岁和5060.6±2395 ng/ml。总体而言，39例（26.4%）患者有IFG，而13例（8.8%）被诊断为糖尿病。IFG或糖尿病患者与空腹血糖水平正常的患者在平均年龄、每次输血量和平均五年铁蛋白方面存在显著差异。年龄>25岁的患者患IFG（OR=4.7，95%CI：1.3-17，p=0.01）和糖尿病（OR=7.1，95%CI：1-49.2，p=0.04）的风险增加。此外，脾切除患者患IFG的风险更高（OR=4.3，95%CI：1.5-12.1，p=0.005），铁蛋白值>6000 ng/ml与糖尿病风险升高相关（OR=7，95%CI：0.8-60.1，p=0.07）。
我们的结果表明，年龄较大、平均五年铁蛋白、每次输血量以及脾切除术是TM患者发生IFG和糖尿病的危险因素。
