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上消化道手术后铜缺乏性脊髓病。

Copper Deficiency Myelopathy After Upper Gastrointestinal Surgery.

机构信息

University Hospitals Birmingham, Birmingham, United Kingdom.

出版信息

Nutr Clin Pract. 2018 Aug;33(4):515-519. doi: 10.1177/0884533617713955. Epub 2017 Dec 14.

DOI:10.1177/0884533617713955
PMID:28659010
Abstract

A well-functioning alimentary canal is required for adequate nutrient absorption. Disruption to the upper gastrointestinal tract through surgery can lead to micronutrient malnourishment. Copper deficiency has been noted in up to 10% of those undergoing Roux-en-Y gastric bypass surgery, but sequalae are not frequently reported. The resultant deficiency states can have profound and long-term consequences if not realized early and managed appropriately. Here we present a case of copper deficiency myelopathy, a condition indistinguishable from subacute combined degeneration of the spinal cord, following upper gastrointestinal bypass surgery for gastric ulceration, further complicated by inadequate nutrition.

摘要

一个运作良好的消化道是充分吸收营养物质的必要条件。手术对上消化道的破坏可导致微量营养素营养不良。在接受 Roux-en-Y 胃旁路手术的患者中,高达 10%的患者出现铜缺乏,但后遗症并不常见。如果不能早期发现和适当处理,由此产生的缺乏状态可能会产生深远和长期的后果。在这里,我们报告了一例铜缺乏性脊髓病,这是一种与脊髓亚急性联合变性无法区分的疾病,发生在上消化道旁路手术后的胃溃疡,进一步复杂化的是营养不足。

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引用本文的文献

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Copper Deficiency: A Frequently Overlooked Complication After MBS-A Systematic Review and Meta-analysis.铜缺乏症:MBS术后一种常被忽视的并发症——系统评价与荟萃分析
Obes Surg. 2025 Feb;35(2):602-613. doi: 10.1007/s11695-024-07569-8. Epub 2025 Jan 4.
2
Serum copper decrease and cerebellar atrophy in patients with nitrous oxide-induced subacute combined degeneration: two cases report.血清铜降低和氧化亚氮诱导的亚急性联合变性患者小脑萎缩:两例报告。
BMC Neurol. 2021 Dec 4;21(1):471. doi: 10.1186/s12883-021-02496-y.
3
Hyperregenerative macrocytic anaemia: the role of copper and zinc.
高再生性大细胞性贫血:铜和锌的作用。
BMJ Case Rep. 2021 Apr 14;14(4):e241028. doi: 10.1136/bcr-2020-241028.
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Progressive myeloneuropathy with symptomatic anaemia.进行性脊髓神经病伴症状性贫血
BMJ Case Rep. 2019 Dec 2;12(12):e230025. doi: 10.1136/bcr-2019-230025.