Frieder Jillian, Kivelevitch Dario, Menter Alan
Division of Dermatology, Baylor University Medical Center, 3900 Junius Street, Suite 125, Dallas, TX 75246, USA.
Ther Deliv. 2017 Aug;8(9):737-746. doi: 10.4155/tde-2017-0058. Epub 2017 Jun 29.
Psoriasis is a common chronic immune-mediated skin disease which has a significant impact on patients' quality of life, and is associated with numerous comorbidities (i.e., psoriatic arthritis, Crohn's disease and cardiovascular disease). A greater understanding of its immunopathogenesis has guided the development of novel, more targeted therapies. Nonetheless, traditional treatment with topical agents, phototherapy and systemic medications is used in the management of the majority of psoriasis patients. Mainstay topical treatments include corticosteroids and vitamin D derivatives. Calcipotriene/betamethasone dipropionate aerosol foam is a novel single product combination, which seeks to provide superior therapeutic efficacy in addition to enhanced cosmetic properties. This article reviews the literature on the pharmacology and clinical data in terms of safety, efficacy and patient satisfaction of this topical medication.
银屑病是一种常见的慢性免疫介导性皮肤病，对患者的生活质量有重大影响，并与多种合并症（如银屑病关节炎、克罗恩病和心血管疾病）相关。对其免疫发病机制的更深入了解推动了新型、更具针对性疗法的发展。尽管如此，大多数银屑病患者的治疗仍采用外用药物、光疗和全身用药等传统治疗方法。主要的外用治疗药物包括皮质类固醇和维生素D衍生物。卡泊三醇/倍他米松二丙酸酯气雾剂泡沫是一种新型单一产品组合，旨在除了增强美容效果外，还能提供卓越的治疗效果。本文就这种外用药物在安全性、疗效和患者满意度方面的药理学和临床数据进行综述。
