School of Pharmacy, Weifang Medical University, Weifang, China.
Basic Medical School, Weifang Medical University, Weifang, China.
Drug Deliv. 2022 Dec;29(1):1903-1913. doi: 10.1080/10717544.2022.2086944.
Oxidative stress due to excessive reactive oxygen species (ROS) production in the skin microenvironment is one of the main mechanisms in psoriasis pathogenesis. A nano drug delivery system based on ROS-responsive release can enhance drug release at the target site. In this study, a ROS-sensitive material methoxypolyethylene glycol-thioether-thiol (mPEG-SS) was synthesized using mPEG as the parent structure with sulfide structural modification. An mPEG-SS-calcipotriol (mPEG-SS-CPT, PSC) nano-micelle percutaneous delivery system was prepared by encapsulating CPT. A small animal imaging system was used to study PSC's the ROS-sensitive drug release process. It is shown that endogenous ROS mainly affects PSC and releases drugs. Finally, the therapeutic effect of PSC on psoriasis was explored by animal experiments. Ultimately, it ameliorates imiquimod-induced psoriasis-like inflammation. Overall, PSC is an effective ROS-sensitive transdermal drug delivery system that is expected to provide a new strategy for treating psoriasis.
皮肤微环境中过量活性氧（ROS）产生导致的氧化应激是银屑病发病机制的主要机制之一。一种基于 ROS 响应性释放的纳米药物递送系统可以增强药物在靶部位的释放。在这项研究中，使用甲氧基聚乙二醇（mPEG）作为母体结构，通过硫代结构修饰，合成了一种 ROS 敏感材料甲氧基聚乙二醇-硫醚-硫（mPEG-SS）。通过包封钙泊三醇（mPEG-SS-CPT，PSC）制备了 mPEG-SS-钙泊三醇（mPEG-SS-CPT，PSC）纳米胶束经皮给药系统。小动物成像系统用于研究 PSC 的 ROS 敏感药物释放过程。结果表明，内源性 ROS 主要影响 PSC 并释放药物。最后，通过动物实验探讨了 PSC 对银屑病的治疗作用。最终，改善了咪喹莫特诱导的银屑病样炎症。总的来说，PSC 是一种有效的 ROS 敏感经皮给药系统，有望为治疗银屑病提供新策略。
