Kazan Kemal
Commonwealth Scientific and Industrial Research Organisation Agriculture and Food, BrisbaneQLD, Australia.
Queensland Alliance for Agriculture and Food Innovation, Queensland Bioscience Precinct, The University of Queensland, BrisbaneQLD, Australia.
Front Plant Sci. 2017 Jun 12;8:999. doi: 10.3389/fpls.2017.00999. eCollection 2017.
The multi-subunit Mediator complex, which links DNA-bound transcription factors to RNA Pol II during transcription, is an essential regulator of gene expression in all eukaryotes. Individual subunits of the Mediator complex integrate numerous endogenous and exogenous signals. In this paper, diverse regulatory functions performed by MEDIATOR25 (MED25), one of the subunits of the plant Mediator complex are reviewed. MED25 was first identified as a regulator of flowering time and named PHYTOCHROME AND FLOWERING TIME1 (PFT1). Since then, MED25 has been implicated in a range of other plant functions that vary from hormone signaling (JA, ABA, ethylene, and IAA) to biotic and abiotic stress tolerance and plant development. MED25 physically interacts with transcriptional activators (e.g., AP2/ERFs, MYCs, and ARFs), repressors (e.g., JAZs and Aux/IAAs), and other Mediator subunits (MED13 and MED16). In addition, various genetic and epigenetic interactions involving MED25 have been reported. These features make MED25 one of the most multifunctional Mediator subunits and provide new insights into the transcriptional control of gene expression in plants.
多亚基中介体复合物在转录过程中将与DNA结合的转录因子与RNA聚合酶II连接起来，是所有真核生物中基因表达的重要调节因子。中介体复合物的各个亚基整合了众多内源性和外源性信号。本文综述了植物中介体复合物亚基之一的MEDIATOR25（MED25）所执行的多种调节功能。MED25最初被鉴定为开花时间的调节因子，并被命名为光敏色素与开花时间1（PFT1）。从那时起，MED25就被认为参与了一系列其他植物功能，从激素信号传导（茉莉酸、脱落酸、乙烯和生长素）到生物和非生物胁迫耐受性以及植物发育。MED25与转录激活因子（如AP2/ERF、MYC和ARF）、阻遏因子（如JAZ和Aux/IAA）以及其他中介体亚基（MED13和MED16）发生物理相互作用。此外，还报道了涉及MED25的各种遗传和表观遗传相互作用。这些特性使MED25成为最具多功能性的中介体亚基之一，并为植物基因表达的转录调控提供了新的见解。
