植物中介体复合物及其在茉莉酸信号转导中的作用。
The plant Mediator complex and its role in jasmonate signaling.
机构信息
State Key Laboratory of Plant Genomics, National Center for Plant Gene Research (Beijing), Institute of Genetics and Developmental Biology, The Innovative Academy of Seed Design, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
出版信息
J Exp Bot. 2019 Jul 5;70(13):3415-3424. doi: 10.1093/jxb/erz233.
The Mediator complex is an essential, multisubunit transcriptional coactivator that is highly conserved in eukaryotes. Mediator interacts with gene-specific transcription factors, the RNA polymerase II transcriptional machinery, as well as several other factors involved in transcription, and acts as an integral hub to regulate various aspects of transcription. Recent studies of the plant Mediator complex have established that it functions in diverse aspects of plant development and fitness. Jasmonate (JA) is an oxylipin-derived plant hormone that regulates plant immunity and development. The basic helix-loop-helix transcription factor MYC2, which is a master regulator of JA signaling, orchestrates genome-wide transcriptional reprogramming of plant cells to coordinate defense- and growth-related processes. Here, we review the function of the plant Mediator complex in regulating JA signaling. We focus on the multifunctional Mediator subunit MED25, which emerges as an integrative hub for the transcriptional regulation of jasmonate signaling.
中介复合物是一种必需的、多亚基转录共激活因子，在真核生物中高度保守。中介复合物与基因特异性转录因子、RNA 聚合酶 II 转录机制以及其他几个参与转录的因子相互作用，作为一个整体枢纽，调节转录的各个方面。最近对植物中介复合物的研究表明，它在植物发育和适应性的各个方面发挥作用。茉莉酸（JA）是一种由氧化脂肪衍生的植物激素，调节植物的免疫和发育。基本螺旋-环-螺旋转录因子 MYC2 是 JA 信号的主要调节因子，它协调植物细胞的全基因组转录重编程，以协调防御和生长相关的过程。在这里，我们回顾了植物中介复合物在调节 JA 信号中的功能。我们专注于多功能的中介复合物亚基 MED25，它作为 jasmonate 信号转录调控的集成枢纽出现。
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