Homrich J G, Gentil C G, Peres-Polon V L, Covian M R
Braz J Med Biol Res. 1985;18(1):15-27.
To study the role played by neurotransmitters and their receptor mechanisms in the control of feeding behavior elicited by electrical stimulation, drugs that affect neurotransmission were injected via cannula electrodes into the lateral hypothalamic area. Pretreatment with noradrenaline (0.5 and 1.0 nmol) significantly increased the effect of hypothalamic stimulation on feeding, whereas injection of 1.0, 2.0 and 4.0 nmol of adrenaline or dopamine was ineffective. Phentolamine (40.0, 80.0 and 100.0 nmol) and propranolol (40.0, 80.0 and 120.0 nmol) induced a decrease in food intake, suggesting the involvement of both alpha and beta receptors in this mechanism. However, isoprenaline (20.0 nmol) also reduced food intake. Reduction of food intake by propranolol was probably related to the action of the local anesthetic. Alphamethyl-p-tyrosine (203.0 nmol), reserpine (32.8 nmol) and 6-hydroxydopamine (200.0 nmol) inhibited the feeding behavior elicited by electrical stimulation of the lateral hypothalamic area. These results suggest that electrical stimulation of the lateral hypothalamic area elicits feeding behavior by releasing noradrenaline. Alpha-adrenergic receptors seem to play a facilitatory role in feeding behavior.
为研究神经递质及其受体机制在电刺激诱发的摄食行为控制中所起的作用，通过套管电极将影响神经传递的药物注入下丘脑外侧区。用去甲肾上腺素（0.5和1.0纳摩尔）预处理可显著增强下丘脑刺激对摄食的影响，而注射1.0、2.0和4.0纳摩尔的肾上腺素或多巴胺则无效。酚妥拉明（40.0、80.0和100.0纳摩尔）和普萘洛尔（40.0、80.0和120.0纳摩尔）可导致食物摄入量减少，提示α和β受体均参与此机制。然而，异丙肾上腺素（20.0纳摩尔）也可减少食物摄入量。普萘洛尔导致食物摄入量减少可能与局部麻醉作用有关。α-甲基-对-酪氨酸（203.0纳摩尔）、利血平（32.8纳摩尔）和6-羟基多巴胺（200.0纳摩尔）可抑制下丘脑外侧区电刺激诱发的摄食行为。这些结果表明，下丘脑外侧区的电刺激通过释放去甲肾上腺素诱发摄食行为。α-肾上腺素能受体似乎在摄食行为中起促进作用。
