Watt C B, Li H B, Lam D M
Brain Res. 1985 Nov 25;348(1):187-91. doi: 10.1016/0006-8993(85)90378-6.
Amacrine cells are retinal interneurons which serve to mediate transmission between bipolar and ganglion cells. To date, in addition to several classical neurotransmitters, a number of neuroactive peptides have been localized to these cells. We have previously demonstrated in the chicken that both peptide-transmitter and peptide-peptide colocalization exists in some amacrine cells. In this report, we show that 3 neuroactive peptides (enkephalin, neurotensin and somatostatin) are present in subpopulations of amacrine cells which also possess a high affinity uptake system for glycine. These observations suggest that the simultaneous visualization by autoradiography of [3H]glycine-uptake and immunocytochemistry of peptides may be useful for distinguishing between different types of putative glycinergic amacrine cells.
无长突细胞是视网膜中间神经元，用于介导双极细胞和神经节细胞之间的信号传递。迄今为止，除了几种经典神经递质外，许多神经活性肽也已在这些细胞中定位。我们之前在鸡身上证明，一些无长突细胞中存在肽递质和肽肽共定位现象。在本报告中，我们表明3种神经活性肽（脑啡肽、神经降压素和生长抑素）存在于无长突细胞亚群中，这些细胞还具有对甘氨酸的高亲和力摄取系统。这些观察结果表明，通过放射自显影同时显示[3H]甘氨酸摄取和肽的免疫细胞化学，可能有助于区分不同类型的假定甘氨酸能无长突细胞。
