Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka, 569-1094, Japan.
Environ Sci Pollut Res Int. 2017 Aug;24(23):19021-19030. doi: 10.1007/s11356-017-9525-0. Epub 2017 Jun 28.
The distributions of 31 pharmaceuticals grouped into nine therapeutic classes, including six anticancer drugs, were investigated in the waters and sediments of an urban river in Japan. The coefficients of sorption (logK ) to the river sediments were also determined from the results of a field survey and laboratory-scale experiment. Three anticancer drugs-bicalutamide, doxifluridine, and tamoxifen-were detected in the river sediments at maximum concentrations of 391, 392, and 250 ng/kg, respectively. In addition, the transformation products of psychotropic carbamazepine (2-hydroxy carbamazepine, acridine, and acridone) were detected in the range of 108 ng/kg (2-hydroxy carbamazepine) to 2365 ng/kg (acridine), and the phytoestrogen glycitein was detected in the range of N.D. to 821 ng/kg. The logK values of the targeted pharmaceuticals in river sediments in the field survey ranged from 0.5 (theophylline) to 3.3 (azithromycin). These results were in accord with those of the laboratory-scale sorption experiment. To the best of our knowledge, this is the first report of the detection of the anticancer drugs bicalutamide and tamoxifen, the transformation products of carbamazepine (2-hydroxy carbamazepine, acridine, and acridone), and the phytoestrogen genistein in river sediments.
研究了日本一条城市河流中的水和沉积物中 31 种药物（分为 9 个治疗类别，包括 6 种抗癌药物）的分布情况。还从野外调查和实验室规模实验的结果中确定了对河流沉积物的吸附系数（logK）。在河底沉积物中检测到三种抗癌药物-比卡鲁胺、多西氟尿苷和他莫昔芬，其浓度分别为 391、392 和 250ng/kg。此外，在 108ng/kg（2-羟基卡马西平）至 2365ng/kg（吖啶）的范围内检测到精神药物卡马西平的转化产物（2-羟基卡马西平、吖啶和吖啶酮），并且在 N.D.到 821ng/kg 的范围内检测到植物雌激素大豆苷元。野外调查中河流沉积物中目标药物的 logK 值范围为 0.5（茶碱）至 3.3（阿奇霉素）。这些结果与实验室规模的吸附实验结果一致。据我们所知，这是首次在河底沉积物中检测到抗癌药物比卡鲁胺和他莫昔芬、卡马西平的转化产物（2-羟基卡马西平、吖啶和吖啶酮）和植物雌激素大豆苷元的报道。
