Department of Neurology, Fujian Medical University Union Hospital, 29 Xinquan Road, Fuzhou, Fujian, 350001, China.
Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, Fujian, 350025, China.
Neurol Sci. 2017 Sep;38(9):1657-1663. doi: 10.1007/s10072-017-3050-2. Epub 2017 Jun 28.
The objective of this study was to explore the feasibility of using wearable devices to quantitatively measure the daily activity in patients with Parkinson's disease (PD) and to monitor medication-induced motor fluctuations. In this case-controlled study, we used monitored daily movement function in 21 patients with Parkinson's disease and 20 healthy volunteers. We analyzed the exercise types and sleep duration in the two groups and evaluated the correlation between daily movement function and age, gender, education, disease duration, Hohn-Yahr stage, UPDRS-II score, UPDRS-III score, and levodopa dose. We also determined the amount of exercise performed by PD patients at 1 h after taking levodopa and at 1 h before the next dose. The type of activity, average speed, and sleep duration in patients were significantly lower in PD patients than in healthy controls (P < 0.05). One hour after taking levodopa, patients were significantly more active than 1 h before the next dose (P < 0.05).Correlation analysis showed that age, gender, education, disease duration, Hohn-Yahr stage, UPDRS-II and UPDRS-III scores, and dosage of levodopa do not correlate with the daily movement function (P > 0.05) in patients with Parkinson's disease. In the control group, age and education were associated with daily movement function (P < 0.05), while gender was unrelated (P > 0.05). Continuous monitoring of daily activity may be useful to reveal medication-induced motor fluctuations in Parkinson's disease. The daily movement function may depend on age and education, but not on other parameters.
本研究旨在探讨使用可穿戴设备定量测量帕金森病（PD）患者日常活动并监测药物引起的运动波动的可行性。在这项病例对照研究中，我们使用监测仪记录了 21 名帕金森病患者和 20 名健康志愿者的日常运动功能。我们分析了两组患者的运动类型和睡眠时间，并评估了日常运动功能与年龄、性别、教育程度、病程、Hohn-Yahr 分期、UPDRS-II 评分、UPDRS-III 评分和左旋多巴剂量之间的相关性。我们还确定了 PD 患者在服用左旋多巴后 1 小时和下一次剂量前 1 小时的运动量。与健康对照组相比，PD 患者的活动类型、平均速度和睡眠时间明显较低（P<0.05）。服用左旋多巴后 1 小时，患者的活动量明显高于下一次剂量前 1 小时（P<0.05）。相关性分析显示，年龄、性别、教育程度、病程、Hohn-Yahr 分期、UPDRS-II 和 UPDRS-III 评分以及左旋多巴剂量与帕金森病患者的日常运动功能无关（P>0.05）。在对照组中，年龄和教育程度与日常运动功能相关（P<0.05），而性别无关（P>0.05）。连续监测日常活动可能有助于揭示帕金森病患者药物引起的运动波动。日常运动功能可能取决于年龄和教育程度，但与其他参数无关。
