铜催化合成 1,2-二取代苯并咪唑的一锅法策略
One-pot strategy of copper-catalyzed synthesis of 1,2-disubstituted benzimidazoles.
作者信息
Xie Caixia, Han Xushuang, Gong Jian, Li Danyang, Ma Chen
机构信息
School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P R China.
School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P R China and State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, P. R. China.
出版信息
Org Biomol Chem. 2017 Jul 21;15(27):5811-5819. doi: 10.1039/c7ob00945c. Epub 2017 Jun 29.
A simple, one-pot and copper-catalyzed coupling reaction for the construction of 1,2-disubstituted benzimidazole derivatives is described. A low-cost copper salt and a weak base KPO were utilized in this reaction. A variety of 1,2-disubstituted benzimidazoles were obtained in moderate to excellent yields.
描述了一种用于构建1,2-二取代苯并咪唑衍生物的简单、一锅法铜催化偶联反应。该反应使用了低成本的铜盐和弱碱KPO。以中等至优异的产率获得了多种1,2-二取代苯并咪唑。
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