冷冻保存的外周血细胞在慢性粒细胞白血病转化患者中作为自体移植物发挥作用。
Cryopreserved peripheral blood cells functioning as autografts in patients with chronic granulocytic leukaemia in transformation.
作者信息
Goldman J M, Catovsky D, Hows J, Spiers A S, Galton D A
出版信息
Br Med J. 1979 May 19;1(6174):1310-3. doi: 10.1136/bmj.1.6174.1310.
Six patients with chronic granulocytic leukaemia (CGL) in transformation were treated with cytotoxic drugs or cytotoxic drugs plus total body irradiation, followed by infusion of reconstituted autologous peripheral blood cells that had been collected from them at diagnosis and stored in liquid nitrogen for up to 58 months. In four cases the blood and bone-marrow appearances were rapidly restored to those of typical chronic-phase disease. In three of these patients transformation recurred at 74, 32, and 26 weeks respectively. One patient was still in second chronic phase at eight weeks. One of the patients who entered a second transformation was restored to a third chronic phase by further treatment with cytotoxic drugs and a second autograft. Cryopreserved autologous blood cells may thus restore some patients with CGL in transformation to chronic-phase disease and so may help to prolong life.
6例慢性粒细胞白血病（CGL）急变期患者接受了细胞毒性药物治疗或细胞毒性药物加全身照射，随后输注了在诊断时采集并液氮保存长达58个月的自体外周血重建细胞。4例患者的血液和骨髓表现迅速恢复至典型慢性期疾病状态。其中3例患者分别在74周、32周和26周时复发急变。1例患者在8周时仍处于第二次慢性期。1例进入第二次急变期的患者通过细胞毒性药物进一步治疗和第二次自体移植恢复至第三次慢性期。因此，冷冻保存的自体血细胞可能使部分CGL急变期患者恢复至慢性期疾病状态，从而有助于延长生存期。
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