Department of Fundamental and Applied Problems of Endocrinology, Institute of Endocrinology and Metabolism, Kyiv, Ukraine.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Int J Cancer. 2017 Oct 15;141(8):1585-1588. doi: 10.1002/ijc.30857. Epub 2017 Jul 10.
To evaluate risk of thyroid neoplasia nearly 30 years following exposure to radioactive iodine (I-131) from the 1986 Chernobyl nuclear accident, we conducted a fifth cycle of thyroid screening of the Ukrainian-American cohort during 2012-2015, following four previous screening cycles started in 1998. We identified 47 thyroid cancers (TC) and 33 follicular adenomas (FA) among 10,073 individuals who were <18 years at the time of the accident and had a mean I-131 dose of 0.62 Gy. We found a significant I-131 dose response for both TC and FA, with an excess odd ratio per Gy of 1.36 (95% CI: 0.39-4.15) and 2.03 (95% CI: 0.55-6.69), respectively. The excess risk of malignant and benign thyroid neoplasia persists nearly three decades after exposure and underscores the importance of continued follow-up of this cohort to characterize long-term pattern of I-131 risk.
为了评估 1986 年切尔诺贝利核事故后近 30 年放射性碘（I-131）暴露对甲状腺肿瘤风险的影响，我们于 2012-2015 年对乌克兰裔美国人队列进行了第五次甲状腺筛查，该队列此前曾在 1998 年进行了四次筛查。在事故发生时年龄小于 18 岁且 I-131 剂量平均为 0.62Gy 的 10073 人中，我们发现了 47 例甲状腺癌（TC）和 33 例滤泡性腺瘤（FA）。我们发现 TC 和 FA 均与 I-131 剂量呈显著正相关，每 Gy 的超额比值分别为 1.36（95%CI：0.39-4.15）和 2.03（95%CI：0.55-6.69）。恶性和良性甲状腺肿瘤的超额风险在暴露后近三十年仍持续存在，这突出表明有必要对该队列进行持续随访，以描述 I-131 风险的长期模式。
