Bouma Brett E, Villiger Martin, Otsuka Kenichiro, Oh Wang-Yuhl
Harvard Medical School and Massachusetts General Hospital, Boston, MA 02171, USA.
Institute for Medical Engineering and Science, Cambridge, MA, 02139, USA.
Biomed Opt Express. 2017 Apr 26;8(5):2660-2686. doi: 10.1364/BOE.8.002660. eCollection 2017 May 1.
Shortly after the first demonstration of optical coherence tomography for imaging the microstructure of the human eye, work began on developing systems and catheters suitable for intravascular imaging in order to diagnose and investigate atherosclerosis and potentially to monitor therapy. This review covers the driving considerations of the clinical application and its constraints, the major engineering milestones that enabled the current, high-performance commercial imaging systems, the key studies that laid the groundwork for image interpretation, and the clinical research that traces intravascular optical coherence tomography (OCT) from early human pilot studies to current clinical trials.
在首次展示用于成像人眼微观结构的光学相干断层扫描技术后不久，人们便开始致力于开发适用于血管内成像的系统和导管，以诊断和研究动脉粥样硬化，并有可能监测治疗效果。本综述涵盖了临床应用的驱动因素及其限制、促成当前高性能商业成像系统的主要工程里程碑、为图像解读奠定基础的关键研究，以及将血管内光学相干断层扫描（OCT）从早期人体初步研究追溯至当前临床试验的临床研究。
