单心动周期三维冠状动脉内光学相干断层扫描术
Single cardiac cycle three-dimensional intracoronary optical coherence tomography.
作者信息
Kim Tae Shik, Park Hyun-Sang, Jang Sun-Joo, Song Joon Woo, Cho Han Saem, Kim Sunwon, Bouma Brett E, Kim Jin Won, Oh Wang-Yuhl
机构信息
Department of Mechanical Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; KI for Health Science and Technology, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; These authors contributed equally to this work.
KI for Health Science and Technology, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; Graduate School of Medical Science and Engineering, KAIST, 291 Daehak-ro, Yuseong-gu, Daejeon, South Korea; Currently at Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; These authors contributed equally to this work.
出版信息
Biomed Opt Express. 2016 Nov 1;7(12):4847-4858. doi: 10.1364/BOE.7.004847. eCollection 2016 Dec 1.
While high-speed intracoronary optical coherence tomography (OCT) provides three-dimensional (3D) visualization of coronary arteries , imaging speeds remain insufficient to avoid motion artifacts induced by heartbeat, limiting the clinical utility of OCT. In this paper, we demonstrate development of a high-speed intracoronary OCT system (frame rate: 500 frames/s, pullback speed: 100 mm/s) along with prospective electrocardiogram (ECG) triggering technology, which enabled volumetric imaging of long coronary segments within a single cardiac cycle (70 mm pullback in 0.7 s) with minimal cardiac motion artifact. This technology permitted detailed visualization of 3D architecture of the coronary arterial wall of a swine and fine structure of the implanted stent.
虽然高速冠状动脉光学相干断层扫描（OCT）可提供冠状动脉的三维（3D）可视化图像，但成像速度仍不足以避免心跳引起的运动伪影，限制了OCT的临床应用。在本文中，我们展示了一种高速冠状动脉OCT系统（帧率：500帧/秒，回撤速度：100毫米/秒）的开发以及前瞻性心电图（ECG）触发技术，该技术能够在单个心动周期内（0.7秒内回撤70毫米）对长冠状动脉节段进行容积成像，且心脏运动伪影最小。这项技术能够详细显示猪冠状动脉壁的三维结构以及植入支架的精细结构。
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