Marosevic Durdica, Kaevska Marija, Jaglic Zoran
Bavarian Health Food Safety Authority, 85764 Oberschleißheim, Germany.
Ann Agric Environ Med. 2017 Jun 12;24(2):338-344. doi: 10.26444/aaem/74718.
An excessive use of antimicrobial agents poses a risk for the selection of resistant bacteria. Of particular interest are antibiotics that have large consumption rates in both veterinary and human medicine, such as the tetracyclines and macrolide-lincosamide-streptogramin (MLS) group of antibiotics. A high load of these agents increases the risk of transmission of resistant bacteria and/or resistance determinants to humans, leading to a subsequent therapeutic failure. An increasing incidence of bacteria resistant to both tetracyclines and MLS antibiotics has been recently observed. This review summarizes the current knowledge on different tetracycline and MLS resistance genes that can be linked together on transposable elements.
过度使用抗菌剂会带来选择耐药菌的风险。特别值得关注的是在兽医学和人类医学中消耗率都很高的抗生素，例如四环素类抗生素以及大环内酯 - 林可酰胺 - 链阳菌素（MLS）类抗生素。这些药物的高使用量增加了耐药菌和/或耐药决定因子传播给人类的风险，进而导致后续治疗失败。最近观察到对四环素类和MLS类抗生素均耐药的细菌发生率在上升。本综述总结了目前关于可在转座元件上连接在一起的不同四环素和MLS耐药基因的知识。
