风湿性多肌痛患者使用阿片类药物的情况。
Opioid use in patients with polymyalgia rheumatica.
作者信息
Richter Michael D, Achenbach Sara J, Zamora-Legoff Jorge A, Crowson Cynthia S, Matteson Eric L
机构信息
Division of Graduate Medical Education, Mayo Clinic College of Medicine, Rochester, MN, USA.
Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA.
出版信息
Clin Exp Rheumatol. 2017 Nov-Dec;35(6):1014-1017. Epub 2017 Jun 29.
OBJECTIVES
To examine the trends of chronic opioid use in patients with polymyalgia rheumatica (PMR) over an 11-year period in Olmsted County, Minnesota, USA and compare use to subjects without the disease.
METHODS
Retrospective data on opioid prescriptions were collected from 2005 to 2015 in a population-based incidence cohort of patients meeting the 2012 American College of Rheumatology classification criteria for PMR alongside comparison subjects. Poisson regression methods were used to compare opioid use between these groups.
RESULTS
244 patients with PMR and 211 non-PMR comparator subjects were included in the study. Rates of chronic opioid use were not significantly different between the two groups. 7.5% of patients with PMR were identified as chronic users by the end of the study period compared with 5.2% of non-PMR subjects. Any opioid use was also not significantly higher in PMR, with relative risk of 1.10 (95% CI 0.97, 1.26, p=0.14). Rates of chronic use among patients over 80 years were higher in both groups.
CONCLUSIONS
Patients with PMR do not appear to have higher rates of opioid use compared with the general population.
目的
在美国明尼苏达州奥尔姆斯特德县，研究11年间风湿性多肌痛（PMR）患者慢性阿片类药物使用趋势，并与未患该疾病的受试者进行比较。
方法
在一个基于人群的发病率队列中，收集2005年至2015年期间符合2012年美国风湿病学会PMR分类标准的患者以及对照受试者的阿片类药物处方回顾性数据。采用泊松回归方法比较两组之间的阿片类药物使用情况。
结果
本研究纳入了244例PMR患者和211例非PMR对照受试者。两组慢性阿片类药物使用率无显著差异。在研究期结束时，7.5%的PMR患者被确定为慢性使用者，而非PMR受试者为5.2%。PMR患者的任何阿片类药物使用也没有显著更高，相对风险为1.10（95%置信区间0.97, 1.26，p = 0.14）。两组中80岁以上患者的慢性使用率均较高。
结论
与普通人群相比，PMR患者的阿片类药物使用率似乎并不更高。
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