Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria, Australia.
Proteomics. 2017 Dec;17(23-24). doi: 10.1002/pmic.201600431. Epub 2017 Oct 12.
Most bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An important group of bacterial adhesins belong to the autotransporter (AT) superfamily, the largest group of secreted and outer membrane proteins in Gram-negative bacteria. AT adhesins possess diverse functions that facilitate bacterial colonisation, survival and persistence, and as such are often associated with increased bacterial fitness and pathogenic potential. In this review, we will describe AIDA-I type AT adhesins, which comprise the biggest and most diverse group in the AT family. We will focus on Escherichia coli proteins and define general aspects of their biogenesis, distribution, structural properties and key roles in infection.
大多数细菌产生黏附分子以促进与宿主细胞的相互作用，并建立成功的感染。细菌黏附素的一个重要群体属于自转运体 (AT) 超家族，这是革兰氏阴性菌中最大的分泌和外膜蛋白群。AT 黏附素具有多种功能，可促进细菌定植、存活和持续存在，因此通常与细菌适应性和致病性增加有关。在这篇综述中，我们将描述 AIDA-I 型 AT 黏附素，它是 AT 家族中最大和最多样化的群体。我们将重点介绍大肠杆菌蛋白，并定义其生物发生、分布、结构特性和在感染中的关键作用的一般方面。
