Marchewka Zofia, Piwowar Agnieszka, Ruzik Sylwia, Długosz Anna
Pracownia Markerów Nefrotoksyczności Środowiskowej Uniwersytetu Medycznego im. Piastów Śląskich we Wrocławiu.
Katedra i Zakład Toksykologii Uniwersytetu Medycznego im. im. Piastów Śląskich we Wrocławiu.
Postepy Hig Med Dosw (Online). 2017 Jun 19;71(0):541-550. doi: 10.5604/01.3001.0010.3835.
In this article the current data, which shows that glutathione S-transferases (GST) class Pi and Mi are interesting and promising biomarkers in acute and chronic inflammatory processes as well as in the oncology, were presented based on the review of the latest experimental and clinical studies. The article shows their characteristics, functions and participation (direct - GST Pi, indirect - GST Mi) in the regulation of signaling pathways of JNK kinases, which are involved in cell differentiation. Overexpression of glutathione S-transferases class Pi and Mi in many cancer cells plays a key role in cancer treatment, making them resistant to chemotherapy. GST isoenzymes are involved in the metabolism of various types of xenobiotics and endogenous substrates, so their altered expression in cancer tissues as well as in serum and urine could be an important potential marker of the cancer and an indicator of oxidative stress. The study shows the role of glutathione S-transferases in redox homeostasis of tumor cells and in the mechanism of resistance to anticancer drugs.
在本文中，基于对最新实验和临床研究的综述，展示了当前的数据，这些数据表明谷胱甘肽S-转移酶（GST）Pi类和Mi类在急性和慢性炎症过程以及肿瘤学中是有趣且有前景的生物标志物。文章展示了它们的特征、功能以及在JNK激酶信号通路调节中的参与情况（直接参与 - GST Pi，间接参与 - GST Mi），而JNK激酶参与细胞分化。谷胱甘肽S-转移酶Pi类和Mi类在许多癌细胞中的过表达在癌症治疗中起关键作用，使癌细胞对化疗产生抗性。GST同工酶参与各种类型的外源性物质和内源性底物的代谢，因此它们在癌组织以及血清和尿液中的表达改变可能是癌症的重要潜在标志物和氧化应激的指标。该研究展示了谷胱甘肽S-转移酶在肿瘤细胞氧化还原稳态以及抗癌药物抗性机制中的作用。
