Department of Biotechnology & Bioinformatics, North-Eastern Hill University, Shillong, Meghalaya, 793022, India.
Department of Urology, Case Western Reserve University, School of Medicine, Cleveland, OH, 44106, USA; The Urology Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, 44106, USA; Department of Nutrition, Case Western Reserve University, Cleveland, OH, 44106, USA; Division of General Medical Sciences, Case Comprehensive Cancer Center, Cleveland, OH, 44106, USA; Department of Urology, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, OH, 44106, USA.
Cancer Lett. 2018 Oct 1;433:33-42. doi: 10.1016/j.canlet.2018.06.028. Epub 2018 Jun 27.
Glutathione S-transferases (GSTs) are phase II detoxifying enzymes involved in the maintenance of cell integrity, oxidative stress and protection against DNA damage by catalyzing the conjugation of glutathione to a wide variety of electrophilic substrates. Though enzymes of the glutathione synthesis and salvage pathways have been well characterized in the past, there is still a lack of comprehensive understanding of their independent and coordinate regulatory mechanisms in carcinogenesis. The present review discusses implication of GST in cancer development and progression, gene polymorphism, drug resistance, signaling and epigenetic regulation involving their role in cancer. It is anticipated that GST especially the GSTP1 class can be developed as a biomarker either used alone or in combination with other biomarkers for early cancer detection and/or diagnosis as well as for future targeted preventive and therapeutic interventions with dietary agents.
谷胱甘肽 S-转移酶（GSTs）是参与细胞完整性维持、氧化应激和防止 DNA 损伤的 II 相解毒酶，通过催化谷胱甘肽与各种亲电底物的结合来实现。虽然过去已经很好地描述了谷胱甘肽合成和挽救途径的酶，但对它们在致癌作用中的独立和协调调节机制仍缺乏全面的了解。本综述讨论了 GST 在癌症发生和发展、基因多态性、耐药性、信号转导和表观遗传调控中的作用及其在癌症中的作用。预计 GST，特别是 GSTP1 类，可以作为生物标志物开发，无论是单独使用还是与其他生物标志物结合使用，用于早期癌症检测和/或诊断，以及未来针对饮食干预的靶向预防和治疗。
