Rubinow D R, Gold P W, Post R M, Ballenger J C
Prog Neuropsychopharmacol Biol Psychiatry. 1985;9(4):393-400. doi: 10.1016/0278-5846(85)90192-7.
Somatostatin is a hypothalamic tetradecapeptide with many central nervous system actions. We investigated a potential role for altered somatostatin activity in affective disorder by measuring somatostatin in the cerebrospinal fluid (CSF) of 47 patients with affective disorder and of 39 normal volunteers. Medication-free depressed patients showed significantly lower levels of CSF somatostatin than normal volunteers (p less than .001) or patients during the improved state (p less than .01). Somatostatin levels were significantly and inversely correlated with duration of sleep on the night of the lumbar puncture (p less than .05). Treatment with carbamazepine reduced CSF somatostatin (p less than .01) in contrast to the absence of effect of imipramine, desmethylimipramine, and lithium carbonate and the significant increase in CSF somatostatin seen in a small group of patients treated with zimelidine. The implications of these findings with respect to attempts to explore the neurobiology of depression are discussed.
生长抑素是一种具有多种中枢神经系统作用的下丘脑十四肽。我们通过测量47例情感障碍患者和39名正常志愿者脑脊液（CSF）中的生长抑素，研究了生长抑素活性改变在情感障碍中的潜在作用。未服用药物的抑郁症患者脑脊液中生长抑素水平显著低于正常志愿者（p＜0.001）或病情改善期的患者（p＜0.01）。生长抑素水平与腰椎穿刺当晚的睡眠时间呈显著负相关（p＜0.05）。与丙咪嗪、去甲丙咪嗪和碳酸锂无作用以及一小部分接受齐美利定治疗的患者脑脊液中生长抑素显著增加相反，卡马西平治疗可降低脑脊液生长抑素水平（p＜0.01）。讨论了这些发现对于探索抑郁症神经生物学研究的意义。
