[精神分裂症患者免疫反应调节的神经介质机制]

[Neuromediator mechanisms of regulating immune reactions in schizophrenics].

作者信息

Aliev N A

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1985;85(9):1382-5.

Abstract

Eighty patients with paranoid schizophrenia were studied for the cell-mediated (T lymphocytes) and humoral (B lymphocytes, immunoglobins A, M and G) immunity. Using stimulants and blockers of dopaminergic (L-DOPA, haloperidol), serotoninergic (reserpine, deseril), cholinergic (galanthamine, benactyzin) and GABA-ergic (lithium hydroxybutyrate, isoniazid) systems, the authors have established that the dopaminergic system intensifies the immune response while serotoninergic, cholinergic and GABA-ergic systems inhibit it. It is postulated that the effect of neuromediatory systems on the immune responses is reciprocal.

摘要

对80例偏执型精神分裂症患者进行了细胞介导（T淋巴细胞）和体液（B淋巴细胞、免疫球蛋白A、M和G）免疫研究。作者使用多巴胺能（左旋多巴、氟哌啶醇）、5-羟色胺能（利血平、地昔帕明）、胆碱能（加兰他敏、苯那辛）和γ-氨基丁酸能（羟基丁酸钠、异烟肼）系统的兴奋剂和阻滞剂，确定多巴胺能系统增强免疫反应，而5-羟色胺能、胆碱能和γ-氨基丁酸能系统则抑制免疫反应。据推测，神经调节系统对免疫反应的作用是相互的。

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