Persian Gulf Marine Biotechnology Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr 75147, Iran; Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran 13169-43551, Iran.
Division of Cardiovascular Medicine, Stanford University, Stanford, CA 94305, USA.
Trends Biotechnol. 2017 Oct;35(10):937-953. doi: 10.1016/j.tibtech.2017.06.002. Epub 2017 Jun 27.
Alzheimer's disease (AD) is a type of dementia that causes major issues for patients' memory, thinking, and behavior. Despite efforts to advance AD diagnostic and therapeutic tools, AD remains incurable due to its complex and multifactorial nature and lack of effective diagnostics/therapeutics. Nanoparticles (NPs) have demonstrated the potential to overcome the challenges and limitations associated with traditional diagnostics/therapeutics. Nanotechnology is now offering new tools and insights to advance our understanding of AD and eventually may offer new hope to AD patients. Here, we review the key roles of nanotechnologies in the recent literature, in both diagnostic and therapeutic aspects of AD, and discuss how these achievements may improve patient prognosis and quality of life.
阿尔茨海默病（AD）是一种痴呆症，会给患者的记忆、思维和行为带来重大问题。尽管人们努力推进 AD 的诊断和治疗工具，但由于其复杂和多因素的性质以及缺乏有效的诊断/治疗方法，AD 仍然无法治愈。纳米颗粒（NPs）已经证明有潜力克服与传统诊断/治疗相关的挑战和限制。纳米技术现在为我们提供了新的工具和见解，以加深我们对 AD 的理解，最终可能为 AD 患者带来新的希望。在这里，我们回顾了纳米技术在 AD 的诊断和治疗方面的最新文献中的关键作用，并讨论了这些成就如何改善患者的预后和生活质量。
