Impicciatore M, Chiavarini M, Morini G, Barocelli E, Molina E, Plazzi P V
Agents Actions. 1985 Sep;16(6):496-500. doi: 10.1007/BF01983653.
In the present study the effects of three structurally different H2-receptor antagonists (cimetidine, ranitidine and oxmetidine) have been investigated on gastric acid and pepsin secretion of eight cats provided with cannulated gastric fistulas. The maximum pepsin output obtained from a set of complete dose-response curves of dimaprit was not statistically different from basal values. In the presence of the H2-antagonists, while the gastric acid secretion induced by dimaprit was competitively antagonized, the pepsin secretion was differently affected. The data obtained on pepsin activity with cimetidine and ranitidine were quite similar to the control values. By contrast, oxmetidine induced a significant increase. The results suggest a very weak involvement of the H2-receptors in pepsin activity and that oxmetidine performance could not be attributable to an H2-receptor block.
在本研究中，已对三种结构不同的H2受体拮抗剂（西咪替丁、雷尼替丁和奥美替丁）对八只装有胃瘘管的猫的胃酸和胃蛋白酶分泌的影响进行了研究。从一组地马普明的完整剂量-反应曲线获得的最大胃蛋白酶输出量与基础值无统计学差异。在H2拮抗剂存在的情况下，虽然地马普明诱导的胃酸分泌受到竞争性拮抗，但胃蛋白酶分泌受到不同影响。用西咪替丁和雷尼替丁获得的胃蛋白酶活性数据与对照值相当相似。相比之下，奥美替丁引起显著增加。结果表明H2受体在胃蛋白酶活性中的参与非常微弱，且奥美替丁的作用不能归因于H2受体阻断。
