生长抑素和甲硫咪特对清醒猫中五肽胃泌素刺激的胃酸和胃蛋白酶分泌快速耐受的影响。

The effects of somatostatin and metiamide on tachyphylaxis of pentagastrin stimulated gastric acid and pepsin secretion in the conscious cat.

Albinus M, Blair E L, Hirst B H, Reed J D, Schally A V, Shaw B

J Physiol. 1977 Apr;266(3):801-17. doi: 10.1113/jphysiol.1977.sp011794.

Abstract

Pentagastrin stimulated gastric acid and pepsin secretions show parallel rates of tachyphylaxis in the conscious cat. The responses to histamine show only slight tachyphylaxis. 2. Somatostatin 10 microng.kg(-1).hr(-1) inhibits pentagastrin but not histamine stimulated acid secretion and inhibits pentagastrin stimulated pepsin secretion. 3. The inhibition of pentagastrin stimulated acid and pepsin secretion by Somatostatin delays the tachyphylaxis of these responses, but the rates of tachyphylaxis when they do subsequently occur are identical. 4. Metiamide 10 mg-kg(-1)-hr(-1) equally inhibits histamine and pentagastrin stimulated acid secretion but does not inhibit pentagastrin stimulated pepsin secretion. 5. Inhibiton of acid secretion during metiamide infusion neither prevents nor delays acid nor pepsin tachyphylaxis. 6. It is suggested that tachyphylaxis of acid and pepsin secretion is a gastrin receptor phenomenon and that Somatostatin occupies or modifies the behaviour of these receptors, preventing tachyphylaxis. Metiamide, however, exerts its action only on the histmine H2-receptor and not the gastrin receptor mechanism, and this apparently does not prevent or delay acid tachyphylaxis.

摘要

在清醒猫中，五肽胃泌素刺激的胃酸和胃蛋白酶分泌呈现出相似的快速耐受率。对组胺的反应仅表现出轻微的快速耐受。2. 生长抑素10微克·千克⁻¹·小时⁻¹可抑制五肽胃泌素刺激的胃酸分泌，但不抑制组胺刺激的胃酸分泌，且可抑制五肽胃泌素刺激的胃蛋白酶分泌。3. 生长抑素对五肽胃泌素刺激的胃酸和胃蛋白酶分泌的抑制作用可延迟这些反应的快速耐受，但随后出现快速耐受时的速率相同。4. 甲硫咪胺10毫克·千克⁻¹·小时⁻¹可同等程度地抑制组胺和五肽胃泌素刺激的胃酸分泌，但不抑制五肽胃泌素刺激的胃蛋白酶分泌。5. 甲硫咪胺输注期间对胃酸分泌的抑制既不能预防也不能延迟胃酸或胃蛋白酶的快速耐受。6. 提示胃酸和胃蛋白酶分泌的快速耐受是一种胃泌素受体现象，生长抑素占据或改变这些受体的行为，从而预防快速耐受。然而，甲硫咪胺仅作用于组胺H2受体，而非胃泌素受体机制，这显然不能预防或延迟胃酸的快速耐受。