Sewing K F, Billian A, Malchow H
Gut. 1980 Sep;21(9):750-2. doi: 10.1136/gut.21.9.750.
The inhibitory effect of ranitidine and cimetidine on pentagastrin stimulated volume, acid and pepsin secretion has been studied in eight healthy volunteers. Both compounds inhibit all measured components of gastric secretion in a dose dependent manner. On a molar basis ranitidine is on average 11.14 times for volume, 13.04 times for acid, and 9.74 times for pepsin secretion more potent than cimetidine as measured by the ID50-values.
在8名健康志愿者中研究了雷尼替丁和西咪替丁对五肽胃泌素刺激的胃液量、胃酸和胃蛋白酶分泌的抑制作用。两种化合物均以剂量依赖性方式抑制胃液分泌的所有测量成分。以摩尔计,通过半数抑制剂量(ID50)值测量,雷尼替丁对胃液量的抑制作用平均比西咪替丁强11.14倍,对胃酸的抑制作用强13.04倍,对胃蛋白酶分泌的抑制作用强9.74倍。