Departamento de Nutrición y Bioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá D.C., Colombia.
Instituto Cajal, CSIC, Madrid, Spain.
Mol Neurobiol. 2018 May;55(5):4453-4462. doi: 10.1007/s12035-017-0667-3. Epub 2017 Jun 30.
Obesity has been associated with increased chronic neuroinflammation and augmented risk of neurodegeneration. This is worsened during the normal aging process when the levels of endogenous gonadal hormones are reduced. In this study, we have assessed the protective actions of tibolone, a synthetic steroid with estrogenic actions, on T98G human astrocytic cells exposed to palmitic acid, a saturated fatty acid used to mimic obesity in vitro. Tibolone improved cell survival, and preserved mitochondrial membrane potential in palmitic acid-treated astrocytic cells. Although we did not find significant actions of tibolone on free radical production, it modulated astrocytic morphology after treatment with palmitic acid. These data suggest that tibolone protects astrocytic cells by preserving both mitochondrial functionality and morphological complexity.
肥胖与慢性神经炎症的增加和神经退行性病变的风险增加有关。当内源性性腺激素水平降低时，这种情况在正常衰老过程中会进一步恶化。在这项研究中，我们评估了替勃龙（一种具有雌激素作用的合成类固醇）对 T98G 人星形胶质细胞的保护作用，这些细胞暴露于棕榈酸中，棕榈酸是一种用于体外模拟肥胖的饱和脂肪酸。替勃龙可改善细胞存活率，并维持棕榈酸处理的星形胶质细胞中的线粒体膜电位。尽管我们没有发现替勃龙对自由基产生有明显作用，但它可调节棕榈酸处理后的星形胶质细胞形态。这些数据表明，替勃龙通过维持线粒体功能和形态复杂性来保护星形胶质细胞。
