急性痛性自身免疫性神经病：吉兰-巴雷综合征的一个变异型。
Acute painful autoimmune neuropathy: A variant of Guillain-Barré syndrome.
机构信息
Department of Medicine, Yong Loo Lin School of Medicine, National University Singapore, 1E Kent Ridge Road, Singapore, 119228.
Department of Physiology, Yong Loo Lin School of Medicine, National University Singapore, Singapore.
出版信息
Muscle Nerve. 2018 Feb;57(2):320-324. doi: 10.1002/mus.25738. Epub 2017 Jul 24.
INTRODUCTION
We present a painful small-fiber neuropathy variant of Guillain-Barré syndrome characterized by antecedent infectious symptoms, hyporeflexia, and albuminocytologic dissociation.
METHODS
Two patients received intravenous immunoglobulin, one corticosteroids.
RESULTS
The patients subsequently improved. Immunoglobulin G (IgG) antibodies in their acute phase sera strongly bound to murine small nerve fibers, and the binding disappeared during the convalescent phase. Serum transfer to a murine nociceptive model induced transient alteration in thermal pain responses.
DISCUSSION
Our case series suggest that an acute transient immune response can be directed against small nerve fibers, and that patients so affected can exhibit features of Guillain-Barré syndrome. Muscle Nerve 57: 320-324, 2018.
介绍
我们呈现了一种以感染前驱症状、腱反射减弱和蛋白细胞分离为特征的痛性小纤维神经病性吉兰-巴雷综合征变异型。
方法
两名患者接受了静脉注射免疫球蛋白治疗，一名患者接受了皮质类固醇治疗。
结果
患者随后得到改善。他们急性期血清中的 IgG 抗体强烈结合于鼠小神经纤维，而在恢复期时结合消失。血清转移到一种鼠伤害感受模型中，诱导了热痛反应的短暂改变。
讨论
我们的病例系列表明，急性短暂的免疫反应可能针对小神经纤维，受影响的患者可能表现出吉兰-巴雷综合征的特征。肌肉神经 57：320-324，2018.
Zotero 插件