Chelsea and Westminster Hospital, London, U.K.
Center for Chronic Immunodeficiency, University Medical Center Freiburg and University of Freiburg, Freiburg, Germany.
Br J Dermatol. 2018 Sep;179(3):750-754. doi: 10.1111/bjd.15781. Epub 2018 Mar 5.
Invasive dermatophyte infection, with extension beyond the dermis, in immunocompetent hosts is exceptionally rare. Dermatophytes are keratinophilic and are usually confined to the stratum corneum, hair and nails. Susceptibility to dermatophyte infections is incompletely understood, but inherited mutations in key signalling pathways of the innate immune system have been identified. We report the first case of an invasive dermatophyte infection associated with abrupt onset of a prurigo-induced pseudoperforation and a loss-of-function mutation in signal transducer and activator of transcription 3 (STAT3).
在免疫功能正常的宿主中，真皮层以外的侵袭性皮肤癣菌感染极为罕见。皮肤癣菌是嗜角蛋白的，通常局限于角质层、毛发和指甲。对皮肤癣菌感染的易感性尚未完全了解，但已发现先天免疫系统关键信号通路中的遗传突变。我们报告首例与瘙痒诱导的假性穿孔突然发作和信号转导子和转录激活因子 3（STAT3）功能丧失突变相关的侵袭性皮肤癣菌感染。
