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子宫内膜源性着床失败:这不是病理问题,而是我们未能使发育中的胚胎与具有接受性的子宫内膜同步。

Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium.

机构信息

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas; Department of Obstetrics and Gynecology, Valencia University and INCLIVA, Valencia, Spain; Igenomix, Parc Cientific Valencia University, Valencia, Spain; Department of Obstetrics and Gynecology, Stanford University, Stanford, California.

出版信息

Fertil Steril. 2017 Jul;108(1):15-18. doi: 10.1016/j.fertnstert.2017.05.033.

DOI:10.1016/j.fertnstert.2017.05.033
PMID:28668151
Abstract

Repeated implantation failure (RIF) is an intriguing, massive failure of reproductive treatment in otherwise healthy women leading to the introduction of empirical adjuvant interventions that are costly, inefficient, and frustrating for our patients. In this article, we will try to convince the readers that RIF is neither a stigma nor a mysterious pathology but rather our failure to diagnose and properly synchronize the euploid blastocyst with the patient's personalized window of implantation.

摘要

反复着床失败(RIF)是一种有趣的、大规模的生殖治疗失败,发生在原本健康的女性身上,导致我们的患者引入了昂贵、低效且令人沮丧的经验性辅助干预措施。在本文中,我们将试图让读者相信,RIF 既不是耻辱,也不是神秘的病理学,而是我们未能诊断并正确地将整倍体囊胚与患者的个体化着床窗口同步。

相似文献

1
Implantation failure of endometrial origin: it is not pathology, but our failure to synchronize the developing embryo with a receptive endometrium.子宫内膜源性着床失败:这不是病理问题,而是我们未能使发育中的胚胎与具有接受性的子宫内膜同步。
Fertil Steril. 2017 Jul;108(1):15-18. doi: 10.1016/j.fertnstert.2017.05.033.
2
Recurrent implantation failure is a pathology with a specific transcriptomic signature.反复着床失败是一种具有特定转录组特征的病理。
Fertil Steril. 2017 Jul;108(1):9-14. doi: 10.1016/j.fertnstert.2017.05.028. Epub 2017 Jun 14.
3
Comparing endometrial receptivity array to histologic dating of the endometrium in women with a history of implantation failure.比较子宫内膜容受性阵列与有种植失败史女性子宫内膜的组织学分期。
Syst Biol Reprod Med. 2020 Dec;66(6):347-354. doi: 10.1080/19396368.2020.1824032. Epub 2020 Sep 30.
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Endometrial Receptivity Analysis - a tool to increase an implantation rate in assisted reproduction.子宫内膜容受性分析——一种提高辅助生殖中着床率的工具。
Ceska Gynekol. 2019 Spring;84(3):177-183.
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What a difference two days make: "personalized" embryo transfer (pET) paradigm: a case report and pilot study.两天的变化有多大:“个性化”胚胎移植 (pET) 范例:病例报告和初步研究。
Hum Reprod. 2014 Jun;29(6):1244-7. doi: 10.1093/humrep/deu070. Epub 2014 Apr 15.
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The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure.子宫内膜容受性 array 用于诊断和个性化胚胎移植,以治疗反复着床失败的患者。
Fertil Steril. 2013 Sep;100(3):818-24. doi: 10.1016/j.fertnstert.2013.05.004. Epub 2013 Jun 4.
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Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome.体外受精后反复着床失败患者的子宫内膜整合素表达及其与妊娠结局的关系。
Fertil Steril. 2013 Sep;100(3):825-30. doi: 10.1016/j.fertnstert.2013.05.007. Epub 2013 Jun 10.
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Evaluation of the endometrial receptivity assay and the preimplantation genetic test for aneuploidy in overcoming recurrent implantation failure.评估子宫内膜容受性检测和胚胎植入前非整倍体基因检测在克服反复种植失败中的作用。
J Assist Reprod Genet. 2020 Dec;37(12):2989-2997. doi: 10.1007/s10815-020-01948-7. Epub 2020 Sep 24.
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Endometrial receptivity in eutopic endometrium in patients with endometriosis: it is not affected, and let me show you why.内异症患者在位内膜的容受性:不受影响,且听我细细道来。
Fertil Steril. 2017 Jul;108(1):28-31. doi: 10.1016/j.fertnstert.2017.06.002.
10
Endometrial receptivity in the eutopic endometrium of women with endometriosis: it is affected, and let me show you why.子宫内膜异位症患者在位子宫内膜的容受性:它受到了影响,让我来告诉你原因。
Fertil Steril. 2017 Jul;108(1):19-27. doi: 10.1016/j.fertnstert.2017.05.031. Epub 2017 Jun 14.

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Reprod Med Biol. 2025 Jul 30;24(1):e12670. doi: 10.1002/rmb2.12670. eCollection 2025 Jan-Dec.
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Mettl3/Eed/Ythdc1 regulatory axis controls endometrial receptivity and function.Mettl3/Eed/Ythdc1调控轴控制子宫内膜容受性和功能。
Commun Biol. 2025 Feb 11;8(1):215. doi: 10.1038/s42003-025-07667-y.
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The use of propensity score matching to assess the effectiveness of the endometrial receptivity analysis in patients with recurrent implantation failure.
使用倾向评分匹配法评估子宫内膜容受性分析在反复种植失败患者中的有效性。
Front Endocrinol (Lausanne). 2025 Jan 13;15:1402575. doi: 10.3389/fendo.2024.1402575. eCollection 2024.
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Reprod Biol Endocrinol. 2024 Nov 11;22(1):139. doi: 10.1186/s12958-024-01304-9.
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Efficacy of endometrial receptivity testing for recurrent implantation failure in patients with euploid embryo transfers: study protocol for a randomized controlled trial.子宫内膜容受性检测对整倍体胚胎移植反复着床失败患者的疗效:一项随机对照试验的研究方案。
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