Yotsumoto Fusanori, Yoshikawa Kenichi, Hirakawa Toyofumi, Urushiyama Daichi, Kiyoshima Chihiro, Arima Hisatomi, Kodama Shohta, Nishikawa Hiroaki, Yasunaga Shin'ichiro, Miyamoto Shingo
Department of Obstetrics and Gynecology, Faculty of Medicine, Fukuoka University, Fukuoka, JPN.
Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, JPN.
Cureus. 2024 Mar 29;16(3):e57220. doi: 10.7759/cureus.57220. eCollection 2024 Mar.
Implantation failure due to thin endometrium has emerged as a major cause of infertility. In this study, we aimed to assess the safety and preliminary efficacy of adipose tissue-derived regenerative cells (ADRCs), a source of adipose-derived stem cells, in infertility patients with implantation failure.
Five infertile women with implantation failure despite artificial reproductive technology were enrolled in this study and treated with ADRCs via the intrauterine route. The primary outcome was the incidence of adverse events. Additional outcomes were endometrial thickness after ADRC treatment and pregnancy success after embryo transfer.
There were no adverse events in any patient. There was no elevation of white blood cell count, C-reactive protein, or D-dimer levels. There was a significant difference in endometrial thickness in the secretory phase before versus after intrauterine transplantation of ADRCs (3.8 ± 1.3 mm versus 8.8 ± 2.8 mm, respectively; p<0.05). A gestational sac and fetal heartbeat were detected on transvaginal ultrasound in two of five patients.
Intrauterine infusion of autologous ADRCs is a simple and safe procedure that may ameliorate the endometrial microenvironment in infertile women with implantation failure.
子宫内膜薄导致的着床失败已成为不孕的主要原因。在本研究中，我们旨在评估脂肪组织来源的再生细胞（ADRCs），一种脂肪来源干细胞，对着床失败的不孕患者的安全性和初步疗效。
本研究纳入了5名尽管接受了辅助生殖技术但仍着床失败的不孕女性，并通过宫腔途径用ADRCs进行治疗。主要结局是不良事件的发生率。其他结局包括ADRCs治疗后的子宫内膜厚度以及胚胎移植后的妊娠成功率。
所有患者均未发生不良事件。白细胞计数、C反应蛋白或D-二聚体水平均未升高。ADRCs宫腔移植前后分泌期子宫内膜厚度存在显著差异（分别为3.8±1.3mm和8.8±2.8mm；p<0.05）。5名患者中有2名经阴道超声检测到妊娠囊和胎心。
宫腔内输注自体ADRCs是一种简单且安全的操作，可能改善着床失败的不孕女性的子宫内膜微环境。
